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Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP. Bierhaus A, et al. Among authors: dehmer t. Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Nat Med. 2012. PMID: 22581285
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily.
Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundörfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Stern DM, Arnold B, Nawroth PP. Bierhaus A, et al. Among authors: dehmer t. J Clin Invest. 2004 Dec;114(12):1741-51. doi: 10.1172/JCI18058. J Clin Invest. 2004. PMID: 15599399 Free PMC article.
Oxidative stress in patients with Friedreich ataxia.
Schulz JB, Dehmer T, Schöls L, Mende H, Hardt C, Vorgerd M, Bürk K, Matson W, Dichgans J, Beal MF, Bogdanov MB. Schulz JB, et al. Among authors: dehmer t. Neurology. 2000 Dec 12;55(11):1719-21. doi: 10.1212/wnl.55.11.1719. Neurology. 2000. PMID: 11113228