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The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.
Kha ML, Hesse L, Deisinger F, Sipos B, Röcken C, Arlt A, Sebens S, Helm O, Schäfer H. Kha ML, et al. Among authors: deisinger f. Oncogene. 2019 Feb;38(9):1461-1476. doi: 10.1038/s41388-018-0518-3. Epub 2018 Oct 9. Oncogene. 2019. PMID: 30302023
Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
Stachel I, Geismann C, Aden K, Deisinger F, Rosenstiel P, Schreiber S, Sebens S, Arlt A, Schäfer H. Stachel I, et al. Among authors: deisinger f. J Biol Chem. 2014 Jan 24;289(4):1917-29. doi: 10.1074/jbc.M113.490920. Epub 2013 Dec 5. J Biol Chem. 2014. PMID: 24311782 Free PMC article.