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Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer.
Mol Cancer Ther. 2020 Nov;19(11):2245-2255. doi: 10.1158/1535-7163.MCT-20-0423. Epub 2020 Sep 2.
Mol Cancer Ther. 2020.
PMID: 32879053
Free PMC article.
Review.
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE 3rd, Gangjee A, Matherly LH.
Dekhne AS, et al.
Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9.
Mol Cancer Ther. 2019.
PMID: 31289137
Free PMC article.
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Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Xiang W, Dekhne A, Doshi A, O'Connor C, Hou Z, Matherly LH, Gangjee A.
Xiang W, et al.
Bioorg Med Chem. 2019 Dec 1;27(23):115125. doi: 10.1016/j.bmc.2019.115125. Epub 2019 Oct 17.
Bioorg Med Chem. 2019.
PMID: 31679978
Free PMC article.
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Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Dekhne AS, Ning C, Nayeen MJ, Shah K, Kalpage H, Frühauf J, Wallace-Povirk A, O'Connor C, Hou Z, Kim S, Hüttemann M, Gangjee A, Matherly LH.
Dekhne AS, et al.
Mol Pharmacol. 2020 Jan;97(1):9-22. doi: 10.1124/mol.119.117937. Epub 2019 Nov 9.
Mol Pharmacol. 2020.
PMID: 31707355
Free PMC article.
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Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Golani LK, Islam F, O'Connor C, Dekhne AS, Hou Z, Matherly LH, Gangjee A.
Golani LK, et al. Among authors: dekhne as.
Bioorg Med Chem. 2020 Jun 15;28(12):115544. doi: 10.1016/j.bmc.2020.115544. Epub 2020 May 6.
Bioorg Med Chem. 2020.
PMID: 32503687
Free PMC article.
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Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE, Gangjee A, Matherly LH.
Dekhne AS, et al.
Mol Cancer Ther. 2023 Feb 1;22(2):287. doi: 10.1158/1535-7163.MCT-22-0766.
Mol Cancer Ther. 2023.
PMID: 36602953
No abstract available.
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Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer.
Wallace-Povirk A, O'Connor C, Dekhne AS, Bao X, Nayeen MJ, Schneider M, Katinas JM, Wong-Roushar J, Kim S, Polin L, Li J, Back JB, Dann CE, Gangjee A, Hou Z, Matherly LH.
Wallace-Povirk A, et al. Among authors: dekhne as.
Mol Cancer Ther. 2024 Feb 20. doi: 10.1158/1535-7163.MCT-23-0550. Online ahead of print.
Mol Cancer Ther. 2024.
PMID: 38377173
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