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Sexual development of malaria parasites is inhibited in vitro by the neem extract azadirachtin, and its semi-synthetic analogues.
FEMS Microbiol Lett. 1994 Jul 15;120(3):267-73. doi: 10.1111/j.1574-6968.1994.tb07044.x.
FEMS Microbiol Lett. 1994.
PMID: 7980823
The synthesis of azadirachtin: a potent insect antifeedant.
Ley SV, Abad-Somovilla A, Anderson JC, Ayats C, Bänteli R, Beckmann E, Boyer A, Brasca MG, Brice A, Broughton HB, Burke BJ, Cleator E, Craig D, Denholm AA, Denton RM, Durand-Reville T, Gobbi LB, Göbel M, Gray BL, Grossmann RB, Gutteridge CE, Hahn N, Harding SL, Jennens DC, Jennens L, Lovell PJ, Lovell HJ, de la Puente ML, Kolb HC, Koot WJ, Maslen SL, McCusker CF, Mattes A, Pape AR, Pinto A, Santafianos D, Scott JS, Smith SC, Somers AQ, Spilling CD, Stelzer F, Toogood PL, Turner RM, Veitch GE, Wood A, Zumbrunn C.
Ley SV, et al. Among authors: denholm aa.
Chemistry. 2008;14(34):10683-704. doi: 10.1002/chem.200801103.
Chemistry. 2008.
PMID: 18821532
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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2.
Walker CV, Caravatti G, Denholm AA, Egerton J, Faessler A, Furet P, García-Echeverría C, Gay B, Irving E, Jones K, Lambert A, Press NJ, Woods J.
Walker CV, et al. Among authors: denholm aa.
Bioorg Med Chem Lett. 2000 Oct 16;10(20):2343-6. doi: 10.1016/s0960-894x(00)00476-5.
Bioorg Med Chem Lett. 2000.
PMID: 11055352
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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1.
Furet P, Caravatti G, Denholm AA, Faessler A, Fretz H, García-Echeverría C, Gay B, Irving E, Press NJ, Rahuel J, Schoepfer J, Walker CV.
Furet P, et al. Among authors: denholm aa.
Bioorg Med Chem Lett. 2000 Oct 16;10(20):2337-41. doi: 10.1016/s0960-894x(00)00475-3.
Bioorg Med Chem Lett. 2000.
PMID: 11055351
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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Trifilieff A.
Press NJ, et al.
J Med Chem. 2015 Sep 10;58(17):6747-52. doi: 10.1021/acs.jmedchem.5b00902. Epub 2015 Aug 28.
J Med Chem. 2015.
PMID: 26288344
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Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Tyler JW, Wagner T, Fozard JR, Trifilieff A.
Press NJ, et al.
J Med Chem. 2012 Sep 13;55(17):7472-9. doi: 10.1021/jm300459a. Epub 2012 Aug 30.
J Med Chem. 2012.
PMID: 22889281
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Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.
Cole AG, Metzger A, Brescia MR, Qin LY, Appell KC, Brain CT, Hallett A, Ganju P, Denholm AA, Wareing JR, Ritchie TJ, Drake GM, Bevan SJ, MacGloinn A, McBryde A, Patel V, Oakley PJ, Nunez X, Gstach H, Schneider P, Baldwin JJ, Dolle RE, McDonald E, Henderson I.
Cole AG, et al. Among authors: denholm aa.
Bioorg Med Chem Lett. 2009 Jan 1;19(1):119-22. doi: 10.1016/j.bmcl.2008.11.005. Epub 2008 Nov 6.
Bioorg Med Chem Lett. 2009.
PMID: 19014884
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