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Page 1
Role of the vacuolar ATPase in the Alphavirus replication cycle.
Schuchman RM, Vancini R, Piper A, Breuer D, Ribeiro M, Ferreira D, Magliocca J, Emmerich V, Hernandez R, Brown DT. Schuchman RM, et al. Among authors: breuer d. Heliyon. 2018 Jul 25;4(7):e00701. doi: 10.1016/j.heliyon.2018.e00701. eCollection 2018 Jul. Heliyon. 2018. PMID: 30094371 Free PMC article.
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.
Ammosova T, Obukhov Y, Kotelkin A, Breuer D, Beullens M, Gordeuk VR, Bollen M, Nekhai S. Ammosova T, et al. Among authors: breuer d. PLoS One. 2011 Apr 21;6(4):e18985. doi: 10.1371/journal.pone.0018985. PLoS One. 2011. PMID: 21533037 Free PMC article.
Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.
Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Tyagi M, et al. Among authors: breuer d. Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4. Retrovirology. 2015. PMID: 26178009 Free PMC article.
Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.
Kumari N, Iordanskiy S, Kovalskyy D, Breuer D, Niu X, Lin X, Xu M, Gavrilenko K, Kashanchi F, Dhawan S, Nekhai S. Kumari N, et al. Among authors: breuer d. Antimicrob Agents Chemother. 2014 Nov;58(11):6558-71. doi: 10.1128/AAC.02918-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155598 Free PMC article.
CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.
Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S. Breuer D, et al. Retrovirology. 2012 Nov 9;9:94. doi: 10.1186/1742-4690-9-94. Retrovirology. 2012. PMID: 23140174 Free PMC article.
Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9.
Debebe Z, Ammosova T, Breuer D, Lovejoy DB, Kalinowski DS, Kumar K, Jerebtsova M, Ray P, Kashanchi F, Gordeuk VR, Richardson DR, Nekhai S. Debebe Z, et al. Among authors: breuer d. Mol Pharmacol. 2011 Jan;79(1):185-96. doi: 10.1124/mol.110.069062. Epub 2010 Oct 18. Mol Pharmacol. 2011. PMID: 20956357 Free PMC article.