Densham RM - Search Results

1

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

Butler LR, Densham RM, Jia J, Garvin AJ, Stone HR, Shah V, Weekes D, Festy F, Beesley J, Morris JR. Butler LR, et al. Among authors: densham rm. EMBO J. 2012 Oct 3;31(19):3918-34. doi: 10.1038/emboj.2012.232. Epub 2012 Aug 21. EMBO J. 2012. PMID: 22909820 Free PMC article.

2

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E. Morris JR, et al. Nature. 2009 Dec 17;462(7275):886-90. doi: 10.1038/nature08593. Nature. 2009. PMID: 20016594

3

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.

Garvin AJ, Densham RM, Blair-Reid SA, Pratt KM, Stone HR, Weekes D, Lawrence KJ, Morris JR. Garvin AJ, et al. Among authors: densham rm. EMBO Rep. 2013 Nov;14(11):975-83. doi: 10.1038/embor.2013.141. Epub 2013 Sep 10. EMBO Rep. 2013. PMID: 24018422 Free PMC article.

4

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.

Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid S, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR. Densham RM, et al. Nat Struct Mol Biol. 2016 Jul;23(7):647-55. doi: 10.1038/nsmb.3236. Epub 2016 May 30. Nat Struct Mol Biol. 2016. PMID: 27239795 Free PMC article.

5

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.

Densham RM, Morris JR. Densham RM, et al. Nucleus. 2017 Mar 4;8(2):116-125. doi: 10.1080/19491034.2016.1267092. Epub 2016 Dec 29. Nucleus. 2017. PMID: 28032817 Free PMC article. Review.

6

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

Uckelmann M, Densham RM, Baas R, Winterwerp HHK, Fish A, Sixma TK, Morris JR. Uckelmann M, et al. Among authors: densham rm. Nat Commun. 2018 Jan 15;9(1):229. doi: 10.1038/s41467-017-02653-3. Nat Commun. 2018. PMID: 29335415 Free PMC article.

7

Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11.

Spiliotopoulos A, Blokpoel Ferreras L, Densham RM, Caulton SG, Maddison BC, Morris JR, Dixon JE, Gough KC, Dreveny I. Spiliotopoulos A, et al. Among authors: densham rm. J Biol Chem. 2019 Jan 11;294(2):424-436. doi: 10.1074/jbc.RA118.004469. Epub 2018 Oct 29. J Biol Chem. 2019. PMID: 30373771 Free PMC article.

8

The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.

Garvin AJ, Walker AK, Densham RM, Chauhan AS, Stone HR, Mackay HL, Jamshad M, Starowicz K, Daza-Martin M, Ronson GE, Lanz AJ, Beesley JF, Morris JR. Garvin AJ, et al. Among authors: densham rm. Genes Dev. 2019 Mar 1;33(5-6):333-347. doi: 10.1101/gad.321125.118. Epub 2019 Feb 22. Genes Dev. 2019. PMID: 30796017 Free PMC article.

9

Isomerization of BRCA1-BARD1 promotes replication fork protection.

Daza-Martin M, Starowicz K, Jamshad M, Tye S, Ronson GE, MacKay HL, Chauhan AS, Walker AK, Stone HR, Beesley JFJ, Coles JL, Garvin AJ, Stewart GS, McCorvie TJ, Zhang X, Densham RM, Morris JR. Daza-Martin M, et al. Among authors: densham rm. Nature. 2019 Jul;571(7766):521-527. doi: 10.1038/s41586-019-1363-4. Epub 2019 Jul 3. Nature. 2019. PMID: 31270457

10

Moving Mountains-The BRCA1 Promotion of DNA Resection.

Densham RM, Morris JR. Densham RM, et al. Front Mol Biosci. 2019 Sep 3;6:79. doi: 10.3389/fmolb.2019.00079. eCollection 2019. Front Mol Biosci. 2019. PMID: 31552267 Free PMC article. Review.

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