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Page 1
Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
Cell Rep. 2018 Mar 20;22(12):3251-3264. doi: 10.1016/j.celrep.2018.02.097.
Cell Rep. 2018.
PMID: 29562181
Free PMC article.
Mediator subunit Med15 dictates the conserved "fuzzy" binding mechanism of yeast transcription activators Gal4 and Gcn4.
Tuttle LM, Pacheco D, Warfield L, Wilburn DB, Hahn S, Klevit RE.
Tuttle LM, et al. Among authors: pacheco d.
Nat Commun. 2021 Apr 13;12(1):2220. doi: 10.1038/s41467-021-22441-4.
Nat Commun. 2021.
PMID: 33850123
Free PMC article.
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Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA.
Donczew R, Warfield L, Pacheco D, Erijman A, Hahn S.
Donczew R, et al. Among authors: pacheco d.
Elife. 2020 Jan 8;9:e50109. doi: 10.7554/eLife.50109.
Elife. 2020.
PMID: 31913117
Free PMC article.
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Transcription Activation Domains of the Yeast Factors Met4 and Ino2: Tandem Activation Domains with Properties Similar to the Yeast Gcn4 Activator.
Pacheco D, Warfield L, Brajcich M, Robbins H, Luo J, Ranish J, Hahn S.
Pacheco D, et al.
Mol Cell Biol. 2018 Apr 30;38(10):e00038-18. doi: 10.1128/MCB.00038-18. Print 2018 May 15.
Mol Cell Biol. 2018.
PMID: 29507182
Free PMC article.
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Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains.
Herbig E, Warfield L, Fish L, Fishburn J, Knutson BA, Moorefield B, Pacheco D, Hahn S.
Herbig E, et al. Among authors: pacheco d.
Mol Cell Biol. 2010 May;30(10):2376-90. doi: 10.1128/MCB.01046-09. Epub 2010 Mar 22.
Mol Cell Biol. 2010.
PMID: 20308326
Free PMC article.
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A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface.
Warfield L, Tuttle LM, Pacheco D, Klevit RE, Hahn S.
Warfield L, et al. Among authors: pacheco d.
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3506-13. doi: 10.1073/pnas.1412088111. Epub 2014 Aug 13.
Proc Natl Acad Sci U S A. 2014.
PMID: 25122681
Free PMC article.
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The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.
Brzovic PS, Heikaus CC, Kisselev L, Vernon R, Herbig E, Pacheco D, Warfield L, Littlefield P, Baker D, Klevit RE, Hahn S.
Brzovic PS, et al. Among authors: pacheco d.
Mol Cell. 2011 Dec 23;44(6):942-53. doi: 10.1016/j.molcel.2011.11.008.
Mol Cell. 2011.
PMID: 22195967
Free PMC article.
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