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The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.
Clavreul L, Bernard L, Cotte AK, Hennuyer N, Bourouh C, Devos C, Helleboid A, Haas JT, Verrijken A, Gheeraert C, Derudas B, Guille L, Chevalier J, Eeckhoute J, Vallez E, Dorchies E, Van Gaal L, Lassailly G, Francque S, Staels B, Paumelle R. Clavreul L, et al. Among authors: derudas b. Metabolism. 2024 Feb;151:155720. doi: 10.1016/j.metabol.2023.155720. Epub 2023 Nov 3. Metabolism. 2024. PMID: 37926201
Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.
Mysiorek C, Culot M, Dehouck L, Derudas B, Staels B, Bordet R, Cecchelli R, Fenart L, Berezowski V. Mysiorek C, et al. Among authors: derudas b. Curr Neurovasc Res. 2009 Aug;6(3):181-93. doi: 10.2174/156720209788970081. Epub 2009 Aug 1. Curr Neurovasc Res. 2009. PMID: 19534718
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.
Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B. Chinetti-Gbaguidi G, et al. Among authors: derudas b. Circ Res. 2011 Apr 15;108(8):985-95. doi: 10.1161/CIRCRESAHA.110.233775. Epub 2011 Feb 24. Circ Res. 2011. PMID: 21350215 Free PMC article.
Downregulation of the tumour suppressor p16INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotype.
Fuentes L, Wouters K, Hannou SA, Cudejko C, Rigamonti E, Mayi TH, Derudas B, Pattou F, Chinetti-Gbaguidi G, Staels B, Paumelle R. Fuentes L, et al. Among authors: derudas b. Diabetologia. 2011 Dec;54(12):3150-6. doi: 10.1007/s00125-011-2324-0. Epub 2011 Oct 4. Diabetologia. 2011. PMID: 21968977 Free PMC article.
Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages.
Chinetti-Gbaguidi G, Bouhlel MA, Copin C, Duhem C, Derudas B, Neve B, Noel B, Eeckhoute J, Lefebvre P, Seckl JR, Staels B. Chinetti-Gbaguidi G, et al. Among authors: derudas b. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):677-85. doi: 10.1161/ATVBAHA.111.241364. Epub 2011 Dec 29. Arterioscler Thromb Vasc Biol. 2012. PMID: 22207732 Free PMC article.
Liver X receptor activation stimulates iron export in human alternative macrophages.
Bories G, Colin S, Vanhoutte J, Derudas B, Copin C, Fanchon M, Daoudi M, Belloy L, Haulon S, Zawadzki C, Jude B, Staels B, Chinetti-Gbaguidi G. Bories G, et al. Among authors: derudas b. Circ Res. 2013 Nov 8;113(11):1196-205. doi: 10.1161/CIRCRESAHA.113.301656. Epub 2013 Sep 13. Circ Res. 2013. PMID: 24036496 Free PMC article.
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