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Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F. Prieto Huarcaya S, et al. Among authors: di spiezio a. Autophagy. 2022 May;18(5):1127-1151. doi: 10.1080/15548627.2022.2045534. Epub 2022 Apr 28. Autophagy. 2022. PMID: 35287553 Free PMC article.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Marques ARA, Di Spiezio A, Thießen N, Schmidt L, Grötzinger J, Lüllmann-Rauch R, Damme M, Storck SE, Pietrzik CU, Fogh J, Bär J, Mikhaylova M, Glatzel M, Bassal M, Bartsch U, Saftig P. Marques ARA, et al. Among authors: di spiezio a. Autophagy. 2020 May;16(5):811-825. doi: 10.1080/15548627.2019.1637200. Epub 2019 Jul 16. Autophagy. 2020. PMID: 31282275 Free PMC article.
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals.
Pedram K, Laqtom NN, Shon DJ, Di Spiezio A, Riley NM, Saftig P, Abu-Remaileh M, Bertozzi CR. Pedram K, et al. Among authors: di spiezio a. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2117105119. doi: 10.1073/pnas.2117105119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122205 Free PMC article.
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.
Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU. Storck SE, et al. Among authors: di spiezio a. J Clin Invest. 2016 Jan;126(1):123-36. doi: 10.1172/JCI81108. Epub 2015 Nov 30. J Clin Invest. 2016. PMID: 26619118 Free PMC article.
The LepR-mediated leptin transport across brain barriers controls food reward.
Di Spiezio A, Sandin ES, Dore R, Müller-Fielitz H, Storck SE, Bernau M, Mier W, Oster H, Jöhren O, Pietrzik CU, Lehnert H, Schwaninger M. Di Spiezio A, et al. Mol Metab. 2018 Feb;8:13-22. doi: 10.1016/j.molmet.2017.12.001. Epub 2017 Dec 7. Mol Metab. 2018. PMID: 29254602 Free PMC article.
Nesfatin-1 decreases the motivational and rewarding value of food.
Dore R, Krotenko R, Reising JP, Murru L, Sundaram SM, Di Spiezio A, Müller-Fielitz H, Schwaninger M, Jöhren O, Mittag J, Passafaro M, Shanabrough M, Horvath TL, Schulz C, Lehnert H. Dore R, et al. Among authors: di spiezio a. Neuropsychopharmacology. 2020 Sep;45(10):1645-1655. doi: 10.1038/s41386-020-0682-3. Epub 2020 Apr 30. Neuropsychopharmacology. 2020. PMID: 32353862 Free PMC article.
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