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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Nature. 2000 Jun 8;405(6787):689-94. doi: 10.1038/35015085.
Nature. 2000.
PMID: 10864326
gamma-Secretase: characterization and implication for Alzheimer disease therapy.
Xu M, Lai MT, Huang Q, DiMuzio-Mower J, Castro JL, Harrison T, Nadin A, Neduvelil JG, Shearman MS, Shafer JA, Gardell SJ, Li YM.
Xu M, et al. Among authors: dimuzio mower j.
Neurobiol Aging. 2002 Nov-Dec;23(6):1023-30. doi: 10.1016/s0197-4580(02)00126-4.
Neurobiol Aging. 2002.
PMID: 12470798
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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM.
Lai MT, et al. Among authors: dimuzio mower j.
J Biol Chem. 2003 Jun 20;278(25):22475-81. doi: 10.1074/jbc.M300974200. Epub 2003 Apr 8.
J Biol Chem. 2003.
PMID: 12684521
Free article.
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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ.
Li YM, et al. Among authors: dimuzio mower j.
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6138-43. doi: 10.1073/pnas.110126897.
Proc Natl Acad Sci U S A. 2000.
PMID: 10801983
Free PMC article.
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Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.
Coburn CA, Rush DM, Williams PD, Homnick C, Lyle EA, Lewis SD, Lucas BJ Jr, Di Muzio-Mower JM, Juliano M, Krueger JA, Vastag K, Chen IW, Vacca JP.
Coburn CA, et al.
Bioorg Med Chem Lett. 2000 May 15;10(10):1069-72. doi: 10.1016/s0960-894x(00)00170-0.
Bioorg Med Chem Lett. 2000.
PMID: 10843219
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