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Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes.
Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Nathan DM, et al. N Engl J Med. 2005 Dec 22;353(25):2643-53. doi: 10.1056/NEJMoa052187. N Engl J Med. 2005. PMID: 16371630 Free PMC article. Clinical Trial.
We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease. METHODS: The DCCT randomly …
We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Compl
Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up.
Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Diabetes Care. 2016 May;39(5):686-93. doi: 10.2337/dc15-1990. Epub 2016 Feb 9. Diabetes Care. 2016. PMID: 26861924 Free PMC article. Clinical Trial.
We now assess whether intensive therapy compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the incidence of cardiovascular disease over 30 years of follow-up. RESEARCH DESIGN AND METHODS
We now assess whether intensive therapy compared with conventional therapy during the Diabetes Control and Complications
Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population.
Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Diabetes Care. 2016 Aug;39(8):1378-83. doi: 10.2337/dc15-2399. Epub 2016 Jul 13. Diabetes Care. 2016. PMID: 27411699 Free PMC article.
OBJECTIVE: Historically, mortality in type 1 diabetes has exceeded that in the general population. We compared mortality in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complicat
OBJECTIVE: Historically, mortality in type 1 diabetes has exceeded that in the general population. We compared mortality in the Di
Comparison of digital and film grading of diabetic retinopathy severity in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.
Hubbard LD, Sun W, Cleary PA, Danis RP, Hainsworth DP, Peng Q, Susman RA, Aiello LP, Davis MD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Hubbard LD, et al. Arch Ophthalmol. 2011 Jun;129(6):718-26. doi: 10.1001/archophthalmol.2011.136. Arch Ophthalmol. 2011. PMID: 21670338 Clinical Trial.
OBJECTIVE: To compare diabetic retinopathy (DR) severity as evaluated by digital and film images in a long-term multicenter study, as the obsolescence of film forced the Diabetes Control and Complications Trial/Epidemiology of Diabetes
OBJECTIVE: To compare diabetic retinopathy (DR) severity as evaluated by digital and film images in a long-term multicenter study, as …
Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort.
de Boer IH, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group; White NH, Danis RP, Davis MD, Hainsworth D, Hubbard LD, Nathan DM. de Boer IH, et al. Arch Intern Med. 2011 Mar 14;171(5):412-20. doi: 10.1001/archinternmed.2011.16. Arch Intern Med. 2011. PMID: 21403038 Free PMC article. Clinical Trial.
BACKGROUND: Microalbuminuria is a common diagnosis in the clinical care of patients with type 1 diabetes mellitus. Long-term outcomes after the development of microalbuminuria are variable. METHODS: We quantified the incidence of and risk factors for l …
BACKGROUND: Microalbuminuria is a common diagnosis in the clinical care of patients with type 1 diabetes mellitus. Long …
Long-term effect of diabetes and its treatment on cognitive function.
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group; Jacobson AM, Musen G, Ryan CM, Silvers N, Cleary P, Waberski B, Burwood A, Weinger K, Bayless M, Dahms W, Harth J. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group, et al. N Engl J Med. 2007 May 3;356(18):1842-52. doi: 10.1056/NEJMoa066397. N Engl J Med. 2007. PMID: 17476010 Free PMC article. Clinical Trial.
METHODS: A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC
METHODS: A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications
Longitudinal changes in estimated and measured GFR in type 1 diabetes.
de Boer IH, Sun W, Cleary PA, Lachin JM, Molitch ME, Zinman B, Steffes MW; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. de Boer IH, et al. J Am Soc Nephrol. 2014 Apr;25(4):810-8. doi: 10.1681/ASN.2013050557. Epub 2013 Dec 5. J Am Soc Nephrol. 2014. PMID: 24309189 Free PMC article.
In cross-sectional and longitudinal analyses of 1441 participants in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study with type 1 diab
In cross-sectional and longitudinal analyses of 1441 participants in the Diabetes Control and Complications Trial
Circulating vitamin D metabolites and kidney disease in type 1 diabetes.
de Boer IH, Sachs MC, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. de Boer IH, et al. J Clin Endocrinol Metab. 2012 Dec;97(12):4780-8. doi: 10.1210/jc.2012-2852. Epub 2012 Sep 18. J Clin Endocrinol Metab. 2012. PMID: 22990096 Free PMC article.
DESIGN: We performed a cohort study of 1193 participants in the Diabetes Control and Complications Trial (DCCT), a randomized clinical trial of intensive diabetes therapy, and its observational follow-up, the Epidemiology
DESIGN: We performed a cohort study of 1193 participants in the Diabetes Control and Complications Trial (DCC
Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus.
de Boer IH, Kestenbaum B, Rue TC, Steffes MW, Cleary PA, Molitch ME, Lachin JM, Weiss NS, Brunzell JD; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. de Boer IH, et al. Arch Intern Med. 2008 Sep 22;168(17):1867-73. doi: 10.1001/archinternmed.2008.2. Arch Intern Med. 2008. PMID: 18809813 Free PMC article.
BACKGROUND: Diabetes mellitus and hypertension are closely linked, but the long-term blood pressure effects of glucose-lowering therapy and hyperglycemia are not clear. METHODS: We examined the effects of intensive insulin therapy and hyperglycemia on the dev …
BACKGROUND: Diabetes mellitus and hypertension are closely linked, but the long-term blood pressure effects of glucose-lowerin …
Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes.
Sachs MC, Brunzell JD, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Zinman B, de Boer IH; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Sachs MC, et al. Diabetes Care. 2013 Aug;36(8):2423-9. doi: 10.2337/dc12-2020. Epub 2013 Mar 25. Diabetes Care. 2013. PMID: 23530012 Free PMC article.
We tested associations of circulating vitamin D metabolite concentrations with subclinical atherosclerosis among 1,193 participants with type 1 diabetes in the DCCT/EDIC study. RESEARCH DESIGN AND METHODS: We measured plasma concentrations of 25-hydrox …
We tested associations of circulating vitamin D metabolite concentrations with subclinical atherosclerosis among 1,193 participants with typ …
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