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SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
Wang D, Lin Y, Xu F, Zhang H, Zhu X, Liu Z, Hu Y, Dong G, Sun B, Yu Y, Ma G, Tang Z, Legarda D, Ting A, Liu Y, Hou J, Dong L, Xiong H. Wang D, et al. Among authors: legarda d. EBioMedicine. 2022 Nov;85:104278. doi: 10.1016/j.ebiom.2022.104278. Epub 2022 Oct 3. EBioMedicine. 2022. PMID: 36202053 Free PMC article.
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.
Taft J, Markson M, Legarda D, Patel R, Chan M, Malle L, Richardson A, Gruber C, Martín-Fernández M, Mancini GMS, van Laar JAM, van Pelt P, Buta S, Wokke BHA, Sabli IKD, Sancho-Shimizu V, Chavan PP, Schnappauf O, Khubchandani R, Cüceoğlu MK, Özen S, Kastner DL, Ting AT, Aksentijevich I, Hollink IHIM, Bogunovic D. Taft J, et al. Among authors: legarda d. Cell. 2021 Aug 19;184(17):4447-4463.e20. doi: 10.1016/j.cell.2021.07.026. Epub 2021 Aug 6. Cell. 2021. PMID: 34363755 Free PMC article.
Interleukin-1β-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation.
Hu Y, Xu F, Zhang R, Legarda D, Dai J, Wang D, Li H, Zhang Y, Xue Q, Dong G, Zhang H, Lu C, Mortha A, Liu J, Cravedi P, Ting A, Li L, Qi CF, Pierce S, Merad M, Heeger P, Xiong H. Hu Y, et al. Among authors: legarda d. J Autoimmun. 2019 Aug;102:50-64. doi: 10.1016/j.jaut.2019.04.010. Epub 2019 May 10. J Autoimmun. 2019. PMID: 31080014
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