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Development of an mRNA replacement therapy for phenylketonuria.
Perez-Garcia CG, Diaz-Trelles R, Vega JB, Bao Y, Sablad M, Limphong P, Chikamatsu S, Yu H, Taylor W, Karmali PP, Tachikawa K, Chivukula P. Perez-Garcia CG, et al. Among authors: diaz trelles r. Mol Ther Nucleic Acids. 2022 Feb 28;28:87-98. doi: 10.1016/j.omtn.2022.02.020. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35356682 Free PMC article.
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.
Diaz-Trelles R, Lee S, Kuakini K, Park J, Dukanovic A, Gonzalez JA, Dam T, Kim JH, Vega JB, Sablad M, Karmali PP, Tachikawa K, Chivukula P. Diaz-Trelles R, et al. Mol Genet Metab Rep. 2022 May 14;32:100882. doi: 10.1016/j.ymgmr.2022.100882. eCollection 2022 Sep. Mol Genet Metab Rep. 2022. PMID: 35600090 Free PMC article.
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation.
Latorre J, Díaz-Trelles R, Comas F, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Ortega F, Castells-Nobau A, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, López M, Giralt M, Fernández-Real JM, Moreno-Navarrete JM. Latorre J, et al. Among authors: diaz trelles r. Mol Ther Nucleic Acids. 2022 Aug 5;29:599-613. doi: 10.1016/j.omtn.2022.08.003. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090751 Free PMC article.
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice.
Comas F, Díaz-Trelles R, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Latorre J, Ortega F, Arnoriaga-Rodriguez M, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, Giralt M, López M, Fernández-Real JM, Moreno-Navarrete JM. Comas F, et al. Among authors: diaz trelles r. Biomed Pharmacother. 2022 Jul;151:113156. doi: 10.1016/j.biopha.2022.113156. Epub 2022 May 25. Biomed Pharmacother. 2022. PMID: 35643066 Free article.
24 results