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Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma.
Hung MH, Lee JS, Ma C, Diggs LP, Heinrich S, Chang CW, Ma L, Forgues M, Budhu A, Chaisaingmongkol J, Ruchirawat M, Ruppin E, Greten TF, Wang XW. Hung MH, et al. Among authors: diggs lp. Nat Commun. 2021 Mar 5;12(1):1455. doi: 10.1038/s41467-021-21804-1. Nat Commun. 2021. PMID: 33674593 Free PMC article.
Steatohepatitis Impairs T-cell-Directed Immunotherapies Against Liver Tumors in Mice.
Heinrich B, Brown ZJ, Diggs LP, Vormehr M, Ma C, Subramanyam V, Rosato U, Ruf B, Walz JS, McVey JC, Wabitsch S, Fu Q, Yu SJ, Zhang Q, Lai CW, Sahin U, Greten TF. Heinrich B, et al. Among authors: diggs lp. Gastroenterology. 2021 Jan;160(1):331-345.e6. doi: 10.1053/j.gastro.2020.09.031. Epub 2020 Oct 1. Gastroenterology. 2021. PMID: 33010248 Free PMC article.
CD40-mediated immune cell activation enhances response to anti-PD-1 in murine intrahepatic cholangiocarcinoma.
Diggs LP, Ruf B, Ma C, Heinrich B, Cui L, Zhang Q, McVey JC, Wabitsch S, Heinrich S, Rosato U, Lai W, Subramanyam V, Longerich T, Loosen SH, Luedde T, Neumann UP, Desar S, Kleiner D, Gores G, Wang XW, Greten TF. Diggs LP, et al. J Hepatol. 2021 May;74(5):1145-1154. doi: 10.1016/j.jhep.2020.11.037. Epub 2020 Dec 1. J Hepatol. 2021. PMID: 33276030 Free PMC article.
Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma.
Zhang Q, Ma C, Duan Y, Heinrich B, Rosato U, Diggs LP, Ma L, Roy S, Fu Q, Brown ZJ, Wabitsch S, Thovarai V, Fu J, Feng D, Ruf B, Cui LL, Subramanyam V, Frank KM, Wang S, Kleiner DE, Ritz T, Rupp C, Gao B, Longerich T, Kroemer A, Wang XW, Ruchirawat M, Korangy F, Schnabl B, Trinchieri G, Greten TF. Zhang Q, et al. Among authors: diggs lp. Cancer Discov. 2021 May;11(5):1248-1267. doi: 10.1158/2159-8290.CD-20-0304. Epub 2020 Dec 15. Cancer Discov. 2021. PMID: 33323397 Free PMC article.
Anti-PD-1 in Combination With Trametinib Suppresses Tumor Growth and Improves Survival of Intrahepatic Cholangiocarcinoma in Mice.
Wabitsch S, Tandon M, Ruf B, Zhang Q, McCallen JD, McVey JC, Ma C, Green BL, Diggs LP, Heinrich B, Greten TF. Wabitsch S, et al. Among authors: diggs lp. Cell Mol Gastroenterol Hepatol. 2021;12(3):1166-1178. doi: 10.1016/j.jcmgh.2021.05.011. Epub 2021 May 23. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34033968 Free PMC article.
Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response.
Ruf B, Catania VV, Wabitsch S, Ma C, Diggs LP, Zhang Q, Heinrich B, Subramanyam V, Cui LL, Pouzolles M, Evans CN, Chari R, Sakai S, Oh S, Barry CE 3rd, Barber DL, Greten TF. Ruf B, et al. Among authors: diggs lp. Cancer Immunol Res. 2021 Sep;9(9):1024-1034. doi: 10.1158/2326-6066.CIR-20-0925. Epub 2021 Jun 30. Cancer Immunol Res. 2021. PMID: 34193462 Free PMC article.
The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma.
Heinrich B, Gertz EM, Schäffer AA, Craig A, Ruf B, Subramanyam V, McVey JC, Diggs LP, Heinrich S, Rosato U, Ma C, Yan C, Hu Y, Zhao Y, Shen TW, Kapoor V, Telford W, Kleiner DE, Stovroff MK, Dhani HS, Kang J, Fishbein T, Wang XW, Ruppin E, Kroemer A, Greten TF, Korangy F. Heinrich B, et al. Among authors: diggs lp. Gut. 2022 Jun;71(6):1161-1175. doi: 10.1136/gutjnl-2021-325288. Epub 2021 Aug 2. Gut. 2022. PMID: 34340996 Free PMC article.
43 results