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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: dimmeler s. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MHH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M. Guarani V, et al. Among authors: dimmeler s. Nature. 2011 May 12;473(7346):234-8. doi: 10.1038/nature09917. Epub 2011 Apr 17. Nature. 2011. PMID: 21499261 Free PMC article.
MicroRNA-34a regulates cardiac ageing and function.
Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. Boon RA, et al. Among authors: dimmeler s. Nature. 2013 Mar 7;495(7439):107-10. doi: 10.1038/nature11919. Epub 2013 Feb 20. Nature. 2013. PMID: 23426265
Cellular cross-talks in the diseased and aging heart.
Wagner JUG, Dimmeler S. Wagner JUG, et al. Among authors: dimmeler s. J Mol Cell Cardiol. 2020 Jan;138:136-146. doi: 10.1016/j.yjmcc.2019.11.152. Epub 2019 Nov 26. J Mol Cell Cardiol. 2020. PMID: 31783034 Free article. Review.
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes.
Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S. Bojkova D, et al. Among authors: dimmeler s. Cardiovasc Res. 2020 Dec 1;116(14):2207-2215. doi: 10.1093/cvr/cvaa267. Cardiovasc Res. 2020. PMID: 32966582 Free PMC article.
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants.
Wagner JUG, Bojkova D, Shumliakivska M, Luxán G, Nicin L, Aslan GS, Milting H, Kandler JD, Dendorfer A, Heumueller AW, Fleming I, Bibli SI, Jakobi T, Dieterich C, Zeiher AM, Ciesek S, Cinatl J, Dimmeler S. Wagner JUG, et al. Among authors: dimmeler s. Basic Res Cardiol. 2021 Jul 5;116(1):42. doi: 10.1007/s00395-021-00882-8. Basic Res Cardiol. 2021. PMID: 34224022 Free PMC article.
Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease.
Cremer S, Pilgram L, Berkowitsch A, Stecher M, Rieg S, Shumliakivska M, Bojkova D, Wagner JUG, Aslan GS, Spinner C, Luxán G, Hanses F, Dolff S, Piepel C, Ruppert C, Guenther A, Rüthrich MM, Vehreschild JJ, Wille K, Haselberger M, Heuzeroth H, Hansen A, Eschenhagen T, Cinatl J, Ciesek S, Dimmeler S, Borgmann S, Zeiher A; LEOSS study group. Cremer S, et al. Among authors: dimmeler s. PLoS One. 2021 Oct 21;16(10):e0258684. doi: 10.1371/journal.pone.0258684. eCollection 2021. PLoS One. 2021. PMID: 34673795 Free PMC article.
DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts.
Shumliakivska M, Luxán G, Hemmerling I, Scheller M, Li X, Müller-Tidow C, Schuhmacher B, Sun Z, Dendorfer A, Debes A, Glaser SF, Muhly-Reinholz M, Kirschbaum K, Hoffmann J, Nagel E, Puntmann VO, Cremer S, Leuschner F, Abplanalp WT, John D, Zeiher AM, Dimmeler S. Shumliakivska M, et al. Among authors: dimmeler s. Nat Commun. 2024 Jan 19;15(1):606. doi: 10.1038/s41467-023-43003-w. Nat Commun. 2024. PMID: 38242884 Free PMC article.
537 results