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Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.
Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Satola SW, Ramalingam SS, Curran WJ, Doetsch PW, Deng X. Chen G, et al. Among authors: doetsch pw. J Clin Invest. 2018 Jan 2;128(1):500-516. doi: 10.1172/JCI92742. Epub 2017 Dec 11. J Clin Invest. 2018. PMID: 29227281 Free PMC article.
c-Myc suppression of DNA double-strand break repair.
Li Z, Owonikoko TK, Sun SY, Ramalingam SS, Doetsch PW, Xiao ZQ, Khuri FR, Curran WJ, Deng X. Li Z, et al. Among authors: doetsch pw. Neoplasia. 2012 Dec;14(12):1190-202. doi: 10.1593/neo.121258. Neoplasia. 2012. PMID: 23308051 Free PMC article.
Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase.
Xie M, Yen Y, Owonikoko TK, Ramalingam SS, Khuri FR, Curran WJ, Doetsch PW, Deng X. Xie M, et al. Among authors: doetsch pw. Cancer Res. 2014 Jan 1;74(1):212-23. doi: 10.1158/0008-5472.CAN-13-1536-T. Epub 2013 Nov 6. Cancer Res. 2014. PMID: 24197132 Free PMC article.
Bcl2 inhibition of mitochondrial DNA repair.
Xie M, Doetsch PW, Deng X. Xie M, et al. Among authors: doetsch pw. BMC Cancer. 2015 Aug 13;15:586. doi: 10.1186/s12885-015-1594-1. BMC Cancer. 2015. PMID: 26268226 Free PMC article.
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS. Zhang H, et al. Among authors: doetsch pw. Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4. Cell Rep. 2016. PMID: 26854234 Free PMC article.
Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Fan J, Lin R, Xia S, Chen D, Elf SE, Liu S, Pan Y, Xu H, Qian Z, Wang M, Shan C, Zhou L, Lei QY, Li Y, Mao H, Lee BH, Sudderth J, DeBerardinis RJ, Zhang G, Owonikoko T, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Kang S, Doetsch PW, Lonial S, Boggon TJ, Curran WJ, Chen J. Fan J, et al. Among authors: doetsch pw. Mol Cell. 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014. Epub 2016 Nov 17. Mol Cell. 2016. PMID: 27867011 Free PMC article.
134 results