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Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis.
Doheny D, Sirkisoon S, Carpenter RL, Aguayo NR, Regua AT, Anguelov M, Manore SG, Arrigo A, Jalboush SA, Wong GL, Yu Y, Wagner CJ, Chan M, Ruiz J, Thomas A, Strowd R, Lin J, Lo HW. Doheny D, et al. Oncogene. 2020 Oct;39(42):6589-6605. doi: 10.1038/s41388-020-01454-1. Epub 2020 Sep 14. Oncogene. 2020. PMID: 32929154 Free PMC article.
TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment.
Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Regua AT, Arrigo A, Anguelov M, Pasche B, Debinski W, Watabe K, Lo HW. Sirkisoon SR, et al. Among authors: doheny d. Oncogene. 2020 Jan;39(1):64-78. doi: 10.1038/s41388-019-0959-3. Epub 2019 Aug 28. Oncogene. 2020. PMID: 31462709 Free PMC article.
Hedgehog Signaling and Truncated GLI1 in Cancer.
Doheny D, Manore SG, Wong GL, Lo HW. Doheny D, et al. Cells. 2020 Sep 17;9(9):2114. doi: 10.3390/cells9092114. Cells. 2020. PMID: 32957513 Free PMC article. Review.
TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers.
Regua AT, Aguayo NR, Jalboush SA, Doheny DL, Manore SG, Zhu D, Wong GL, Arrigo A, Wagner CJ, Yu Y, Thomas A, Chan MD, Ruiz J, Jin G, Strowd R, Sun P, Lin J, Lo HW. Regua AT, et al. Among authors: doheny dl. Cancers (Basel). 2021 May 12;13(10):2340. doi: 10.3390/cancers13102340. Cancers (Basel). 2021. PMID: 34066153 Free PMC article.
Correction: TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment.
Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Regua AT, Arrigo A, Anguelov M, Pasche B, Debinski W, Watabe K, Lo HW. Sirkisoon SR, et al. Among authors: doheny d. Oncogene. 2021 Mar;40(12):2338. doi: 10.1038/s41388-020-01620-5. Oncogene. 2021. PMID: 33654200 No abstract available.
Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases.
Sirkisoon SR, Wong GL, Aguayo NR, Doheny DL, Zhu D, Regua AT, Arrigo A, Manore SG, Wagner C, Thomas A, Singh R, Xing F, Jin G, Watabe K, Lo HW. Sirkisoon SR, et al. Among authors: doheny dl. Cancer Lett. 2022 Aug 1;540:215726. doi: 10.1016/j.canlet.2022.215726. Epub 2022 May 16. Cancer Lett. 2022. PMID: 35589002 Free PMC article.
Transgenic mouse models of breast cancer.
Regua AT, Arrigo A, Doheny D, Wong GL, Lo HW. Regua AT, et al. Among authors: doheny d. Cancer Lett. 2021 Sep 28;516:73-83. doi: 10.1016/j.canlet.2021.05.027. Epub 2021 Jun 6. Cancer Lett. 2021. PMID: 34090924 Free PMC article.
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