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Indolin-2-one p38α inhibitors II: Lead optimisation.
Eastwood P, González J, Gómez E, Caturla F, Balagué C, Orellana A, Domínguez M. Eastwood P, et al. Among authors: dominguez m. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5270-3. doi: 10.1016/j.bmcl.2011.07.033. Epub 2011 Jul 19. Bioorg Med Chem Lett. 2011. PMID: 21813275
Indolin-2-one p38α inhibitors III: bioisosteric amide replacement.
Eastwood P, González J, Gómez E, Caturla F, Aguilar N, Mir M, Aiguadé J, Matassa V, Balagué C, Orellana A, Domínguez M. Eastwood P, et al. Among authors: dominguez m. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6253-7. doi: 10.1016/j.bmcl.2011.09.006. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21958544
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors.
Aiguadé J, Balagué C, Carranco I, Caturla F, Domínguez M, Eastwood P, Esteve C, González J, Lumeras W, Orellana A, Preciado S, Roca R, Vidal L, Vidal B. Aiguadé J, et al. Among authors: dominguez m. Bioorg Med Chem Lett. 2012 May 15;22(10):3431-6. doi: 10.1016/j.bmcl.2012.03.099. Epub 2012 Apr 4. Bioorg Med Chem Lett. 2012. PMID: 22521646
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P₁ direct agonists.
Aguilar N, Mir M, Grima PM, López M, Segarra V, Esteban L, Moreno I, Godessart N, Tarrasón G, Domenech T, Vilella D, Armengol C, Córdoba M, Sabaté M, Casals D, Domínguez M. Aguilar N, et al. Among authors: dominguez m. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7672-6. doi: 10.1016/j.bmcl.2012.09.110. Epub 2012 Oct 11. Bioorg Med Chem Lett. 2012. PMID: 23141913
Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases.
Erra M, Taltavull J, Gréco A, Bernal FJ, Caturla JF, Gràcia J, Domínguez M, Sabaté M, Paris S, Soria S, Hernández B, Armengol C, Cabedo J, Bravo M, Calama E, Miralpeix M, Lehner MD. Erra M, et al. Among authors: dominguez m. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123. doi: 10.1021/acsmedchemlett.6b00438. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105286 Free PMC article.
NK1 antagonists based on seven membered lactam scaffolds.
Elliott JM, Carlson EJ, Chicchi GG, Dirat O, Dominguez M, Gerhard U, Jelley R, Jones AB, Kurtz MM, Tsao Kl, Wheeldon A. Elliott JM, et al. Among authors: dominguez m. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2929-32. doi: 10.1016/j.bmcl.2006.02.080. Epub 2006 Mar 29. Bioorg Med Chem Lett. 2006. PMID: 16574413
1,321 results