Domanico PL - Search Results

1

17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1.

Tian G, Stuart JD, Moss ML, Domanico PL, Bramson HN, Patel IR, Kadwell SH, Overton LK, Kost TA, Mook RA Jr, et al. Tian G, et al. Among authors: domanico pl. Biochemistry. 1994 Mar 1;33(8):2291-6. doi: 10.1021/bi00174a041. Biochemistry. 1994. PMID: 8117686

2

Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate.

Tian G, Rocque WJ, Wiseman JS, Thompson IZ, Holmes WD, Domanico PL, Stafford JA, Feldman PL, Luther MA. Tian G, et al. Among authors: domanico pl. Biochemistry. 1998 May 12;37(19):6894-904. doi: 10.1021/bi972700v. Biochemistry. 1998. PMID: 9578576

3

Association and metabolism of exogenously-derived lysophosphatidylcholine by cultured mammalian cells: kinetics and mechanisms.

Besterman JM, Domanico PL. Besterman JM, et al. Among authors: domanico pl. Biochemistry. 1992 Feb 25;31(7):2046-56. doi: 10.1021/bi00122a022. Biochemistry. 1992. PMID: 1536848

4

Adenosine 5'-O-(3-thiotriphosphate) hydrolysis by dynein.

Shimizu T, Katsura T, Domanico PL, Marchese-Ragona SP, Johnson KA. Shimizu T, et al. Among authors: domanico pl. Biochemistry. 1989 Aug 22;28(17):7022-7. doi: 10.1021/bi00443a036. Biochemistry. 1989. PMID: 2531007

5

Mechanistic studies on E. coli DNA topoisomerase I: divalent ion effects.

Domanico PL, Tse-Dinh YC. Domanico PL, et al. J Inorg Biochem. 1991 May 1;42(2):87-96. doi: 10.1016/0162-0134(91)80035-g. J Inorg Biochem. 1991. PMID: 1649911

6

Phosphodiesterase type IV inhibition. Structure-activity relationships of 1,3-disubstituted pyrrolidines.

Feldman PL, Brackeen MF, Cowan DJ, Marron BE, Schoenen FJ, Stafford JA, Suh EM, Domanico PL, Rose D, Leesnitzer MA, et al. Feldman PL, et al. Among authors: domanico pl. J Med Chem. 1995 Apr 28;38(9):1505-10. doi: 10.1021/jm00009a011. J Med Chem. 1995. PMID: 7739009

7

Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

Brackeen MF, Cowan DJ, Stafford JA, Schoenen FJ, Veal JM, Domanico PL, Rose D, Strickland AB, Verghese M, Feldman PL. Brackeen MF, et al. Among authors: domanico pl. J Med Chem. 1995 Nov 24;38(24):4848-54. doi: 10.1021/jm00024a012. J Med Chem. 1995. PMID: 7490734

8

Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.

Stafford JA, Veal JM, Feldman PL, Valvano NL, Baer PG, Brackeen MF, Brawley ES, Connolly KM, Domanico PL, Han B, et al. Stafford JA, et al. Among authors: domanico pl. J Med Chem. 1995 Dec 22;38(26):4972-5. doi: 10.1021/jm00026a003. J Med Chem. 1995. PMID: 8544172 No abstract available.

9

Unambiguous stereochemical course of rabbit liver fructose bisphosphatase hydrolysis.

Domanico PL, Rahil JF, Benkovic SJ. Domanico PL, et al. Biochemistry. 1985 Mar 26;24(7):1623-8. doi: 10.1021/bi00328a009. Biochemistry. 1985. PMID: 2988606

10

Cleavage of dT8 and dT8 phosphorothioyl analogues by Escherichia coli DNA topoisomerase I: product and rate analysis.

Domanico PL, Tse-Dinh YC. Domanico PL, et al. Biochemistry. 1988 Aug 23;27(17):6365-71. doi: 10.1021/bi00417a026. Biochemistry. 1988. PMID: 2851323

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