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Page 1
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma.
Nat Commun. 2021 Nov 26;12(1):6924. doi: 10.1038/s41467-021-27176-w.
Nat Commun. 2021.
PMID: 34836971
Free PMC article.
PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution.
Asante Y, Benischke K, Osman I, Ngo QA, Wurth J, Laubscher D, Kim H, Udhayakumar B, Khan MIH, Chin DH, Porch J, Chakraborty M, Sallari R, Delattre O, Zaidi S, Morice S, Surdez D, Danielli SG, Schäfer BW, Gryder BE, Wachtel M.
Asante Y, et al. Among authors: laubscher d.
Nat Commun. 2023 Dec 15;14(1):8361. doi: 10.1038/s41467-023-43780-4.
Nat Commun. 2023.
PMID: 38102136
Free PMC article.
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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.
Marques JG, Gryder BE, Pavlovic B, Chung Y, Ngo QA, Frommelt F, Gstaiger M, Song Y, Benischke K, Laubscher D, Wachtel M, Khan J, Schäfer BW.
Marques JG, et al. Among authors: laubscher d.
Elife. 2020 Aug 3;9:e54993. doi: 10.7554/eLife.54993.
Elife. 2020.
PMID: 32744500
Free PMC article.
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Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
Böhm M, Wachtel M, Marques JG, Streiff N, Laubscher D, Nanni P, Mamchaoui K, Santoro R, Schäfer BW.
Böhm M, et al. Among authors: laubscher d.
J Clin Invest. 2016 Nov 1;126(11):4237-4249. doi: 10.1172/JCI85057. Epub 2016 Oct 17.
J Clin Invest. 2016.
PMID: 27760049
Free PMC article.
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Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.
Ommer J, Selfe JL, Wachtel M, O'Brien EM, Laubscher D, Roemmele M, Kasper S, Delattre O, Surdez D, Petts G, Kelsey A, Shipley J, Schäfer BW.
Ommer J, et al. Among authors: laubscher d.
Cancer Res. 2020 Feb 15;80(4):832-842. doi: 10.1158/0008-5472.CAN-19-1479. Epub 2019 Dec 30.
Cancer Res. 2020.
PMID: 31888889
Free article.
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PLK1 phosphorylates PAX3-FOXO1, the inhibition of which triggers regression of alveolar Rhabdomyosarcoma.
Thalhammer V, Lopez-Garcia LA, Herrero-Martin D, Hecker R, Laubscher D, Gierisch ME, Wachtel M, Bode P, Nanni P, Blank B, Koscielniak E, Schäfer BW.
Thalhammer V, et al. Among authors: laubscher d.
Cancer Res. 2015 Jan 1;75(1):98-110. doi: 10.1158/0008-5472.CAN-14-1246. Epub 2014 Nov 14.
Cancer Res. 2015.
PMID: 25398439
Free article.
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Birt-Hogg-Dubé syndrome: novel FLCN frameshift deletion in daughter and father with renal cell carcinomas.
Näf E, Laubscher D, Hopfer H, Streit M, Matyas G.
Näf E, et al. Among authors: laubscher d.
Fam Cancer. 2016 Jan;15(1):127-32. doi: 10.1007/s10689-015-9837-5.
Fam Cancer. 2016.
PMID: 26342594
Free PMC article.
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