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Neuronal membrane cholesterol loss enhances amyloid peptide generation.
Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG. Abad-Rodriguez J, et al. Among authors: dotti cg. J Cell Biol. 2004 Dec 6;167(5):953-60. doi: 10.1083/jcb.200404149. J Cell Biol. 2004. PMID: 15583033 Free PMC article.
Alterations in phosphatidylethanolamine levels affect the generation of Aβ.
Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin F, De Strooper B, Dotti CG, Wahle T. Nesic I, et al. Among authors: dotti cg. Aging Cell. 2012 Feb;11(1):63-72. doi: 10.1111/j.1474-9726.2011.00760.x. Epub 2011 Nov 28. Aging Cell. 2012. PMID: 22023223 Free article.
Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.
Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Guix FX, et al. Among authors: dotti cg. EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. EMBO Mol Med. 2012. PMID: 22488900 Free PMC article.
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.
Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Michaki V, et al. Among authors: dotti cg. J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086926 Free PMC article.
178 results