Dower K - Search Results

1

Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library.

Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Dower K, et al. J Virol. 2012 Mar;86(5):2632-40. doi: 10.1128/JVI.05416-11. Epub 2011 Dec 28. J Virol. 2012. PMID: 22205744 Free PMC article.

2

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J. Filone CM, et al. Among authors: dower k. PLoS Pathog. 2014 Feb 6;10(2):e1003904. doi: 10.1371/journal.ppat.1003904. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24516381 Free PMC article.

3

Formation of antiviral cytoplasmic granules during orthopoxvirus infection.

Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Simpson-Holley M, et al. Among authors: dower k. J Virol. 2011 Feb;85(4):1581-93. doi: 10.1128/JVI.02247-10. Epub 2010 Dec 8. J Virol. 2011. PMID: 21147913 Free PMC article.

4

Myxoma and vaccinia viruses bind differentially to human leukocytes.

Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Chan WM, et al. Among authors: dower k. J Virol. 2013 Apr;87(8):4445-60. doi: 10.1128/JVI.03488-12. Epub 2013 Feb 6. J Virol. 2013. PMID: 23388707 Free PMC article.

5

Vaccinia reporter viruses for quantifying viral function at all stages of gene expression.

Rozelle DK, Filone CM, Dower K, Connor JH. Rozelle DK, et al. Among authors: dower k. J Vis Exp. 2014 May 15;(87):51522. doi: 10.3791/51522. J Vis Exp. 2014. PMID: 24894622 Free PMC article.

6

Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA.

Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH. Filone CM, et al. Among authors: dower k. Assay Drug Dev Technol. 2015 Jan-Feb;13(1):34-43. doi: 10.1089/adt.2014.613. Epub 2015 Feb 3. Assay Drug Dev Technol. 2015. PMID: 25646658 Free PMC article.

7

Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression.

Dower K, Rubins KH, Hensley LE, Connor JH. Dower K, et al. Antiviral Res. 2011 Jul;91(1):72-80. doi: 10.1016/j.antiviral.2011.04.014. Epub 2011 May 5. Antiviral Res. 2011. PMID: 21569797 Free PMC article.

8

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Hall J, et al. Among authors: dower k. PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017. PLoS One. 2017. PMID: 28934246 Free PMC article.

9

A tumor host range selection procedure identifies p150(sal2) as a target of polyoma virus large T antigen.

Li D, Dower K, Ma Y, Tian Y, Benjamin TL. Li D, et al. Among authors: dower k. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14619-24. doi: 10.1073/pnas.251447198. Proc Natl Acad Sci U S A. 2001. PMID: 11734654 Free PMC article.

10

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung S, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, Gavrin LK, Goldberg JA, Han S, Hegen M, Hepworth D, Hope HR, Kamtekar S, Kilty IC, Lee A, Lin LL, Lovering FE, Lowe MD, Mathias JP, Morgan HM, Murphy EA, Papaioannou N, Patny A, Pierce BS, Rao VR, Saiah E, Samardjiev IJ, Samas BM, Shen MWH, Shin JH, Soutter HH, Strohbach JW, Symanowicz PT, Thomason JR, Trzupek JD, Vargas R, Vincent F, Yan J, Zapf CW, Wright SW. Lee KL, et al. Among authors: dower k. J Med Chem. 2017 Jul 13;60(13):5521-5542. doi: 10.1021/acs.jmedchem.7b00231. Epub 2017 Jun 14. J Med Chem. 2017. PMID: 28498658

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