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DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma.
Menzies-Gow A, Ponnarambil S, Downie J, Bowen K, Hellqvist Å, Colice G. Menzies-Gow A, et al. Among authors: downie j. Respir Res. 2020 Oct 21;21(1):279. doi: 10.1186/s12931-020-01541-7. Respir Res. 2020. PMID: 33087119 Free PMC article. Clinical Trial.
Tezepelumab Pharmacokinetics, Safety, and Tolerability After Administration via Vial-and-syringe, Accessorized Prefilled Syringe, or Autoinjector: A Randomized Trial in Healthy Volunteers.
Zheng Y, Abuqayyas L, Megally A, Fuhr R, Sałapa K, Downie J, Colice G. Zheng Y, et al. Among authors: downie j. Clin Ther. 2021 Jan;43(1):142-155.e5. doi: 10.1016/j.clinthera.2020.11.014. Epub 2020 Dec 27. Clin Ther. 2021. PMID: 33380362 Free article. Clinical Trial.
Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.
Mangum DS, Meyer JA, Mason CC, Shams S, Maese LD, Gardiner JD, Downie JM, Pei D, Cheng C, Gleason A, Luo M, Pui CH, Aplenc R, Hunger SP, Loh M, Greaves M, Trede N, Raetz E, Frazer JK, Mullighan CG, Engel ME, Miles RR, Rabin KR, Schiffman JD. Mangum DS, et al. Among authors: downie jm. JAMA Oncol. 2021 Oct 1;7(10):1521-1528. doi: 10.1001/jamaoncol.2021.2723. JAMA Oncol. 2021. PMID: 34410295 Free PMC article.
VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD. Mangum DS, et al. Among authors: downie j. Leukemia. 2014 Jan;28(1):216-20. doi: 10.1038/leu.2013.223. Epub 2013 Jul 24. Leukemia. 2014. PMID: 23881307 Free PMC article. No abstract available.
Shared acquired genomic changes in zebrafish and human T-ALL.
Rudner LA, Brown KH, Dobrinski KP, Bradley DF, Garcia MI, Smith AC, Downie JM, Meeker ND, Look AT, Downing JR, Gutierrez A, Mullighan CG, Schiffman JD, Lee C, Trede NS, Frazer JK. Rudner LA, et al. Among authors: downie jm. Oncogene. 2011 Oct 13;30(41):4289-96. doi: 10.1038/onc.2011.138. Epub 2011 May 9. Oncogene. 2011. PMID: 21552289 Free PMC article.
Genome wide copy number analysis of paediatric Burkitt lymphoma using formalin-fixed tissues reveals a subset with gain of chromosome 13q and corresponding miRNA over expression.
Schiffman JD, Lorimer PD, Rodic V, Jahromi MS, Downie JM, Bayerl MG, Sanmann JN, Althof PA, Sanger WG, Barnette P, Perkins SL, Miles RR. Schiffman JD, et al. Br J Haematol. 2011 Nov;155(4):477-86. doi: 10.1111/j.1365-2141.2011.08883.x. Epub 2011 Oct 8. Br J Haematol. 2011. PMID: 21981616 Free PMC article.
595 results