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A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
Fischer PD, Papadopoulos E, Dempersmier JM, Wang ZF, Nowak RP, Donovan KA, Kalabathula J, Gorgulla C, Junghanns PPM, Kabha E, Dimitrakakis N, Petrov OI, Mitsiades C, Ducho C, Gelev V, Fischer ES, Wagner G, Arthanari H. Fischer PD, et al. Among authors: ducho c. Eur J Med Chem. 2021 Jul 5;219:113435. doi: 10.1016/j.ejmech.2021.113435. Epub 2021 Apr 8. Eur J Med Chem. 2021. PMID: 33892272 Free PMC article.
Enzymatic Cβ-H Functionalization of l-Arg and l-Leu in Nonribosomally Derived Peptidyl Natural Products: A Tale of Two Oxidoreductases.
Cui Z, Nguyen H, Bhardwaj M, Wang X, Büschleb M, Lemke A, Schütz C, Rohrbacher C, Junghanns P, Koppermann S, Ducho C, Thorson JS, Van Lanen SG. Cui Z, et al. Among authors: ducho c. J Am Chem Soc. 2021 Nov 24;143(46):19425-19437. doi: 10.1021/jacs.1c08177. Epub 2021 Nov 12. J Am Chem Soc. 2021. PMID: 34767710 Free PMC article.
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
Fathalla RK, Fröhner W, Bader CD, Fischer PD, Dahlem C, Chatterjee D, Mathea S, Kiemer AK, Arthanari H, Müller R, Abdel-Halim M, Ducho C, Engel M. Fathalla RK, et al. Among authors: ducho c. J Med Chem. 2022 Nov 10;65(21):14740-14763. doi: 10.1021/acs.jmedchem.2c01275. Epub 2022 Oct 21. J Med Chem. 2022. PMID: 36269107 Free PMC article.
79 results