MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis.
Kantar D, Mur EB, Mancini M, Slaninova V, Salah YB, Costa L, Forest E, Lassus P, Géminard C, Boissière-Michot F, Orsetti B, Theillet C, Colinge J, Benistant C, Maraver A, Heron-Milhavet L, Djiane A.
Kantar D, et al. Among authors: slaninova v.
Sci Rep. 2021 Mar 11;11(1):5752. doi: 10.1038/s41598-021-85056-1.
Sci Rep. 2021.
PMID: 33707576
Free PMC article.
We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigenesis. E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased stiffness. …
We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigene …