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16 results

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Page 1
Autophagy promotes cell survival by maintaining NAD levels.
Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI. Kataura T, et al. Among authors: trushina e. Dev Cell. 2022 Nov 21;57(22):2584-2598.e11. doi: 10.1016/j.devcel.2022.10.008. Dev Cell. 2022. PMID: 36413951 Free article.
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE, Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson DG, Frickel EM, Rosenstock TR, Barrett T, Maddocks ODK, Tennant DA, Wang H, Jaenisch R, Korolchuk VI, Sarkar S. Sun C, et al. Among authors: trushina e. Cell Rep. 2023 May 30;42(5):112372. doi: 10.1016/j.celrep.2023.112372. Epub 2023 Apr 21. Cell Rep. 2023. PMID: 37086404 Free PMC article.
A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells.
Hinton A Jr, Katti P, Christensen TA, Mungai M, Shao J, Zhang L, Trushin S, Alghanem A, Jaspersen A, Geroux RE, Neikirk K, Biete M, Lopez EG, Shao B, Vue Z, Vang L, Beasley HK, Marshall AG, Stephens D, Damo S, Ponce J, Bleck CKE, Hicsasmaz I, Murray SA, Edmonds RAC, Dajles A, Koo YD, Bacevac S, Salisbury JL, Pereira RO, Glancy B, Trushina E, Abel ED. Hinton A Jr, et al. Among authors: trushina e. Adv Biol (Weinh). 2023 Oct;7(10):e2200202. doi: 10.1002/adbi.202200202. Epub 2023 May 4. Adv Biol (Weinh). 2023. PMID: 37140138 Free PMC article.
Ergosterol Turnover in Yeast: An Interplay between Biosynthesis and Transport.
Sokolov SS, Trushina NI, Severin FF, Knorre DA. Sokolov SS, et al. Among authors: trushina ni. Biochemistry (Mosc). 2019 Apr;84(4):346-357. doi: 10.1134/S0006297919040023. Biochemistry (Mosc). 2019. PMID: 31228926 Review.
At the same time, disruptions in the biosynthesis of ergosterol, the major sterol of S. cerevisiae, lead to either cell death or reduced stress resistance. However, under certain conditions (e.g., mild salt or thermal stresses), a decrease in the ergosterol levels causes a …
At the same time, disruptions in the biosynthesis of ergosterol, the major sterol of S. cerevisiae, lead to either cell death or reduced str …
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.
Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, Baillie R, Han X, Trojanowski JQ, Shaw LM, Martins R, Weiner MW, Trushina E, Toledo JB, Meikle PJ, Bennett DA, Krumsiek J, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Kastenmüller G. Arnold M, et al. Among authors: trushina e. Nat Commun. 2020 Mar 2;11(1):1148. doi: 10.1038/s41467-020-14959-w. Nat Commun. 2020. PMID: 32123170 Free PMC article.
Moderate ethanol exposure reduces astrocyte-induced neuroinflammatorysignaling and cognitive decline in presymptomatic APP/PS1 mice.
Kang S, Lee J, Choi S, Nesbitt J, Min PH, Trushina E, Choi DS. Kang S, et al. Among authors: trushina e. Res Sq [Preprint]. 2023 Dec 2:rs.3.rs-3627637. doi: 10.21203/rs.3.rs-3627637/v1. Res Sq. 2023. PMID: 38077051 Free PMC article. Preprint.
METHODS: We examined astrocyte function, low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), and the NF-kappaB p65 and IKK-alpha/beta signaling pathways in modulating neuroinflammation and amyloid beta (Abeta) deposition. We assessed apolipoprotein E (ApoE) in …
METHODS: We examined astrocyte function, low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), and the NF-kappaB p65 and IKK-alph …
Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease.
Chang R, Trushina E, Zhu K, Zaidi SSA, Lau BM, Kueider-Paisley A, Moein S, He Q, Alamprese ML, Vagnerova B, Tang A, Vijayan R, Liu Y, Saykin AJ, Brinton RD, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative† and the Alzheimer's Disease Metabolomics Consortium. Chang R, et al. Among authors: trushina e. Alzheimers Dement. 2023 Feb;19(2):518-531. doi: 10.1002/alz.12675. Epub 2022 Apr 28. Alzheimers Dement. 2023. PMID: 35481667 Free PMC article.
Discovery of metabolic profiles unique to sex, apolipoprotein E (APOE) genotype, and stage of disease progression could provide critical insights for personalized LOAD medicine. ...
Discovery of metabolic profiles unique to sex, apolipoprotein E (APOE) genotype, and stage of disease progression could provide criti …
[Effect of microand nanoplastics as food contaminants on the immune system].
Trushina EN, Riger NA, Mustafina OK, Timonin AN. Trushina EN, et al. Vopr Pitan. 2023;92(5):6-15. doi: 10.33029/0042-8833-2023-92-5-6-15. Epub 2023 Sep 26. Vopr Pitan. 2023. PMID: 38198401 Russian.
The results of the studies indicate that MP and NP particles, entering the human body, can move along with the blood and accumulate in various organs: the liver, spleen, heart, lungs, thymus, reproductive organs, kidneys and brain, i.e., to overcome the blood-brain barrier …
The results of the studies indicate that MP and NP particles, entering the human body, can move along with the blood and accumulate in vario …
16 results