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Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484.
Torroni A, Petrozzi M, D'Urbano L, Sellitto D, Zeviani M, Carrara F, Carducci C, Leuzzi V, Carelli V, Barboni P, De Negri A, Scozzari R. Torroni A, et al. Am J Hum Genet. 1997 May;60(5):1107-21. Am J Hum Genet. 1997. PMID: 9150158 Free PMC article.
About the "Asian"-specific 9-bp deletion of mtDNA...
Torroni A, Petrozzi M, Santolamazza P, Sellitto D, Cruciani F, Scozzari R. Torroni A, et al. Am J Hum Genet. 1995 Aug;57(2):507-8. Am J Hum Genet. 1995. PMID: 7668278 Free PMC article. No abstract available.