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Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP. Bierhaus A, et al. Among authors: eberhardt m. Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Nat Med. 2012. PMID: 22581285
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR. Eberhardt M, et al. Nat Commun. 2014 Jul 15;5:4381. doi: 10.1038/ncomms5381. Nat Commun. 2014. PMID: 25023795 Free PMC article.
Etomidate and propylene glycol activate nociceptive TRP ion channels.
Niedermirtl F, Eberhardt M, Namer B, Leffler A, Nau C, Reeh PW, Kistner K. Niedermirtl F, et al. Among authors: eberhardt m. Mol Pain. 2018 Jan-Dec;14:1744806918811699. doi: 10.1177/1744806918811699. Epub 2018 Oct 22. Mol Pain. 2018. PMID: 30345869 Free PMC article.
TRPA1 and substance P mediate colitis in mice.
Engel MA, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović MR, Izydorczyk I, Eberhardt M, Kichko TI, Mueller-Tribbensee SM, Khalil M, Siklosi N, Nau C, Ivanović-Burmazović I, Neuhuber WL, Becker C, Neurath MF, Reeh PW. Engel MA, et al. Among authors: eberhardt m. Gastroenterology. 2011 Oct;141(4):1346-58. doi: 10.1053/j.gastro.2011.07.002. Epub 2011 Jul 18. Gastroenterology. 2011. PMID: 21763243
Bimodal concentration-response of nicotine involves the nicotinic acetylcholine receptor, transient receptor potential vanilloid type 1, and transient receptor potential ankyrin 1 channels in mouse trachea and sensory neurons.
Kichko TI, Lennerz J, Eberhardt M, Babes RM, Neuhuber W, Kobal G, Reeh PW. Kichko TI, et al. Among authors: eberhardt m. J Pharmacol Exp Ther. 2013 Nov;347(2):529-39. doi: 10.1124/jpet.113.205971. Epub 2013 Aug 7. J Pharmacol Exp Ther. 2013. PMID: 23926288
234 results