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H1 histones control the epigenetic landscape by local chromatin compaction.
Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, Sidhwani DS, Wilson TJ, Pinto HB, Maron MI, Skalina KA, Toro LN, Zhao J, Lee CH, Hou H, Yusufova N, Meydan C, Osunsade A, David Y, Cesarman E, Melnick AM, Sidoli S, Garcia BA, Edelmann W, Macian F, Skoultchi AI. Willcockson MA, et al. Among authors: edelmann w. Nature. 2021 Jan;589(7841):293-298. doi: 10.1038/s41586-020-3032-z. Epub 2020 Dec 9. Nature. 2021. PMID: 33299182 Free PMC article.
Mice develop normally without the H1(0) linker histone.
Sirotkin AM, Edelmann W, Cheng G, Klein-Szanto A, Kucherlapati R, Skoultchi AI. Sirotkin AM, et al. Among authors: edelmann w. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6434-8. doi: 10.1073/pnas.92.14.6434. Proc Natl Acad Sci U S A. 1995. PMID: 7604008 Free PMC article.
Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.
He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A. He S, et al. Among authors: edelmann w. Development. 2016 Jun 1;143(11):1937-47. doi: 10.1242/dev.135285. Development. 2016. PMID: 27246713 Free PMC article.
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.
Will B, Vogler TO, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Neriah DB, Roth M, van Oers J, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U. Will B, et al. Among authors: edelmann w. Nat Med. 2015 Oct;21(10):1172-81. doi: 10.1038/nm.3936. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343801 Free PMC article.
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
Chen HJ, Sun J, Huang Z, Hou H Jr, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümüş ZH, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin SM. Chen HJ, et al. Among authors: edelmann w. Nat Biotechnol. 2015 Jun;33(6):656-60. doi: 10.1038/nbt.3239. Epub 2015 May 25. Nat Biotechnol. 2015. PMID: 26006007 Free PMC article.
Cardiac defects and renal failure in mice with targeted mutations in Pkd2.
Wu G, Markowitz GS, Li L, D'Agati VD, Factor SM, Geng L, Tibara S, Tuchman J, Cai Y, Park JH, van Adelsberg J, Hou H Jr, Kucherlapati R, Edelmann W, Somlo S. Wu G, et al. Among authors: edelmann w. Nat Genet. 2000 Jan;24(1):75-8. doi: 10.1038/71724. Nat Genet. 2000. PMID: 10615132
Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.
Avdievich E, Reiss C, Scherer SJ, Zhang Y, Maier SM, Jin B, Hou H Jr, Rosenwald A, Riedmiller H, Kucherlapati R, Cohen PE, Edelmann W, Kneitz B. Avdievich E, et al. Among authors: edelmann w. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4247-52. doi: 10.1073/pnas.0800276105. Epub 2008 Mar 12. Proc Natl Acad Sci U S A. 2008. PMID: 18337503 Free PMC article.
162 results