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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 1
2007 1
2011 1
2012 1
2013 1
2014 2
2015 1
2016 4
2017 4
2018 3
2019 3
2020 1
2021 2
2022 2
2023 5
2024 2

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32 results

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Page 1
Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase.
Gorenflos López JL, Dornan GL, Boback N, Neuenschwander M, Oder A, Kemnitz-Hassanin K, Schmieder P, Specker E, Asikoglu HC, Oberdanner C, Seyffarth C, von Kries JP, Lauster D, Hinderlich S, Hackenberger CPR. Gorenflos López JL, et al. Among authors: specker e. Chembiochem. 2023 Dec 14;24(24):e202300555. doi: 10.1002/cbic.202300555. Epub 2023 Oct 16. Chembiochem. 2023. PMID: 37769151
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
Kücükdisli M, Bel-Abed H, Cirillo D, Lo WT, Efrém NL, Horatscheck A, Perepelittchenko L, Prokofeva P, Ehret TAL, Radetzki S, Neuenschwander M, Specker E, Médard G, Müller S, Wilhelm S, Kuster B, von Kries JP, Haucke V, Nazaré M. Kücükdisli M, et al. Among authors: specker e. J Med Chem. 2023 Oct 26;66(20):14278-14302. doi: 10.1021/acs.jmedchem.3c01319. Epub 2023 Oct 11. J Med Chem. 2023. PMID: 37819647
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
Specker E, Matthes S, Wesolowski R, Schütz A, Grohmann M, Alenina N, Pleimes D, Mallow K, Neuenschwander M, Gogolin A, Weise M, Pfeifer J, Ziebart N, Heinemann U, von Kries JP, Nazaré M, Bader M. Specker E, et al. J Med Chem. 2022 Aug 25;65(16):11126-11149. doi: 10.1021/acs.jmedchem.2c00598. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35921615
Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.
Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K. Bonnekoh H, et al. Among authors: specker e. Clin Transl Allergy. 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. eCollection 2021 Jul. Clin Transl Allergy. 2021. PMID: 34322217 Free PMC article.
NMR quality control of fragment libraries for screening.
Sreeramulu S, Richter C, Kuehn T, Azzaoui K, Blommers MJJ, Del Conte R, Fragai M, Trieloff N, Schmieder P, Nazaré M, Specker E, Ivanov V, Oschkinat H, Banci L, Schwalbe H. Sreeramulu S, et al. Among authors: specker e. J Biomol NMR. 2020 Nov;74(10-11):555-563. doi: 10.1007/s10858-020-00327-9. Epub 2020 Jun 12. J Biomol NMR. 2020. PMID: 32533387 Free PMC article.
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR. Wetzel C, et al. Among authors: specker e. Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12. Nat Neurosci. 2017. PMID: 27941788 Free article.
Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
Jordan P, Costa A, Specker E, Popp O, Volkamer A, Piske R, Obrusnik T, Kleissle S, Stuke K, Rex A, Neuenschwander M, von Kries JP, Nazare M, Mertins P, Kettenmann H, Wolf SA. Jordan P, et al. Among authors: specker e. PLoS One. 2023 Feb 6;18(2):e0278325. doi: 10.1371/journal.pone.0278325. eCollection 2023. PLoS One. 2023. PMID: 36745631 Free PMC article.
CellFy: A Cell-Based Fragment Screen against C-Type Lectins.
Schulze J, Baukmann H, Wawrzinek R, Fuchsberger FF, Specker E, Aretz J, Nazaré M, Rademacher C. Schulze J, et al. Among authors: specker e. ACS Chem Biol. 2018 Dec 21;13(12):3229-3235. doi: 10.1021/acschembio.8b00875. Epub 2018 Dec 3. ACS Chem Biol. 2018. PMID: 30480432
Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands.
Fernández-Bachiller MI, Hwang S, Schembri ME, Lindemann P, Guberman M, Herziger S, Specker E, Matter H, Will DW, Czech J, Wagner M, Bauer A, Schreuder H, Ritter K, Urmann M, Wehner V, Sun H, Nazaré M. Fernández-Bachiller MI, et al. Among authors: specker e. J Med Chem. 2022 Oct 13;65(19):13013-13028. doi: 10.1021/acs.jmedchem.2c00865. Epub 2022 Sep 30. J Med Chem. 2022. PMID: 36178213
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.
Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. Brennecke P, et al. Among authors: specker e. SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7. SLAS Discov. 2019. PMID: 30616481 Free PMC article.
32 results