Edwards DN - Search Results

1

Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy.

Ngwa VM, Edwards DN, Hwang Y, Karno B, Wang X, Yan C, Richmond A, Brantley-Sieders DM, Chen J. Ngwa VM, et al. Among authors: edwards dn. Cancer Res Commun. 2022 Jul;2(7):694-705. doi: 10.1158/2767-9764.crc-22-0048. Epub 2022 Jul 21. Cancer Res Commun. 2022. PMID: 36381236 Free PMC article.

2

The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer.

Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM, Chen J. Youngblood VM, et al. Among authors: edwards dn. Cancer Res. 2016 Apr 1;76(7):1825-36. doi: 10.1158/0008-5472.CAN-15-0847. Epub 2016 Feb 1. Cancer Res. 2016. PMID: 26833123 Free PMC article.

3

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.

Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB, Chen J. Edwards DN, et al. Sci Signal. 2017 Dec 5;10(508):eaan4667. doi: 10.1126/scisignal.aan4667. Sci Signal. 2017. PMID: 29208682 Free PMC article.

4

Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo.

Hwang Y, Kim LC, Song W, Edwards DN, Cook RS, Chen J. Hwang Y, et al. Among authors: edwards dn. Cancer Res. 2019 Jul 1;79(13):3178-3184. doi: 10.1158/0008-5472.CAN-18-3658. Epub 2019 May 13. Cancer Res. 2019. PMID: 31085701 Free PMC article.

5

Microenvironmental Metabolism Regulates Antitumor Immunity.

Ngwa VM, Edwards DN, Philip M, Chen J. Ngwa VM, et al. Among authors: edwards dn. Cancer Res. 2019 Aug 15;79(16):4003-4008. doi: 10.1158/0008-5472.CAN-19-0617. Epub 2019 Jul 30. Cancer Res. 2019. PMID: 31362930 Free PMC article. Review.

6

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.

Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM, Chen J. Song W, et al. Among authors: edwards dn. Mol Cancer Res. 2020 Nov;18(11):1735-1743. doi: 10.1158/1541-7786.MCR-20-0075. Epub 2020 Aug 4. Mol Cancer Res. 2020. PMID: 32753469 Free PMC article.

7

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.

Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J. Wang S, et al. JCI Insight. 2020 Aug 6;5(15):e139237. doi: 10.1172/jci.insight.139237. JCI Insight. 2020. PMID: 32759497 Free PMC article.

8

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.

Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Edwards DN, et al. J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100. J Clin Invest. 2021. PMID: 33320840 Free PMC article.

9

STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy.

Wang-Bishop L, Kimmel BR, Ngwa VM, Madden MZ, Baljon JJ, Florian DC, Hanna A, Pastora LE, Sheehy TL, Kwiatkowski AJ, Wehbe M, Wen X, Becker KW, Garland KM, Schulman JA, Shae D, Edwards D, Wolf MM, Delapp R, Christov PP, Beckermann KE, Balko JM, Rathmell WK, Rathmell JC, Chen J, Wilson JT. Wang-Bishop L, et al. Sci Immunol. 2023 May 12;8(83):eadd1153. doi: 10.1126/sciimmunol.add1153. Epub 2023 May 5. Sci Immunol. 2023. PMID: 37146128

10

Metabolic control of cancer metastasis: role of amino acids at secondary organ sites.

Karno B, Edwards DN, Chen J. Karno B, et al. Among authors: edwards dn. Oncogene. 2023 Nov;42(47):3447-3456. doi: 10.1038/s41388-023-02868-3. Epub 2023 Oct 18. Oncogene. 2023. PMID: 37848626 Review.

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