Edwards GA - Search Results

1

Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation.

Porter CJ, Kaukonen AM, Boyd BJ, Edwards GA, Charman WN. Porter CJ, et al. Among authors: edwards ga. Pharm Res. 2004 Aug;21(8):1405-12. doi: 10.1023/b:pham.0000036914.22132.cc. Pharm Res. 2004. PMID: 15359575

2

A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs.

Khoo SM, Prankerd RJ, Edwards GA, Porter CJ, Charman WN. Khoo SM, et al. Among authors: edwards ga. J Pharm Sci. 2002 Mar;91(3):647-59. doi: 10.1002/jps.10045. J Pharm Sci. 2002. PMID: 11920750

3

Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs.

Shackleford DM, Faassen WA, Houwing N, Lass H, Edwards GA, Porter CJ, Charman WN. Shackleford DM, et al. Among authors: edwards ga. J Pharmacol Exp Ther. 2003 Sep;306(3):925-33. doi: 10.1124/jpet.103.052522. Epub 2003 Jun 13. J Pharmacol Exp Ther. 2003. PMID: 12807999

4

Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep.

McLennan DN, Porter CJ, Edwards GA, Brumm M, Martin SW, Charman SA. McLennan DN, et al. Among authors: edwards ga. Pharm Res. 2003 Aug;20(8):1156-62. doi: 10.1023/a:1025036611949. Pharm Res. 2003. PMID: 12948012

5

Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.

Holm R, Porter CJ, Edwards GA, Müllertz A, Kristensen HG, Charman WN. Holm R, et al. Among authors: edwards ga. Eur J Pharm Sci. 2003 Sep;20(1):91-7. doi: 10.1016/s0928-0987(03)00174-x. Eur J Pharm Sci. 2003. PMID: 13678797

6

Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs.

Khoo SM, Shackleford DM, Porter CJ, Edwards GA, Charman WN. Khoo SM, et al. Among authors: edwards ga. Pharm Res. 2003 Sep;20(9):1460-5. doi: 10.1023/a:1025718513246. Pharm Res. 2003. PMID: 14567642

7

Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine.

Porter CJ, Kaukonen AM, Taillardat-Bertschinger A, Boyd BJ, O'Connor JM, Edwards GA, Charman WN. Porter CJ, et al. Among authors: edwards ga. J Pharm Sci. 2004 May;93(5):1110-21. doi: 10.1002/jps.20039. J Pharm Sci. 2004. PMID: 15067688

8

The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.

McLennan DN, Porter CJ, Edwards GA, Heatherington AC, Martin SW, Charman SA. McLennan DN, et al. Among authors: edwards ga. Pharm Res. 2006 Sep;23(9):2060-6. doi: 10.1007/s11095-006-9064-8. Epub 2006 Aug 9. Pharm Res. 2006. PMID: 16951999

9

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.

Cuiné JF, Charman WN, Pouton CW, Edwards GA, Porter CJ. Cuiné JF, et al. Among authors: edwards ga. Pharm Res. 2007 Apr;24(4):748-57. doi: 10.1007/s11095-006-9194-z. Epub 2007 Feb 15. Pharm Res. 2007. PMID: 17372700

10

Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs.

Cuiné JF, McEvoy CL, Charman WN, Pouton CW, Edwards GA, Benameur H, Porter CJ. Cuiné JF, et al. Among authors: edwards ga. J Pharm Sci. 2008 Feb;97(2):995-1012. doi: 10.1002/jps.21246. J Pharm Sci. 2008. PMID: 18064698

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