Egerland U - Search Results

1

Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.

Malamas MS, Ni Y, Erdei J, Stange H, Schindler R, Lankau HJ, Grunwald C, Fan KY, Parris K, Langen B, Egerland U, Hage T, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Hoefgen N, Brandon NJ. Malamas MS, et al. Among authors: egerland u. J Med Chem. 2011 Nov 10;54(21):7621-38. doi: 10.1021/jm2009138. Epub 2011 Oct 11. J Med Chem. 2011. PMID: 21988093

2

Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.

Höfgen N, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Tremmel P, Pangalos MN, Marquis KL, Hage T, Harrison BL, Malamas MS, Brandon NJ, Kronbach T. Höfgen N, et al. Among authors: egerland u. J Med Chem. 2010 Jun 10;53(11):4399-411. doi: 10.1021/jm1002793. J Med Chem. 2010. PMID: 20450197

3

Novel triazines as potent and selective phosphodiesterase 10A inhibitors.

Malamas MS, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Hage T, Ni Y, Erdei J, Fan KY, Parris K, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Brandon NJ, Hoefgen N. Malamas MS, et al. Among authors: egerland u. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5876-84. doi: 10.1016/j.bmcl.2012.07.076. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22902656

4

Discovery of triazines as potent, selective and orally active PDE4 inhibitors.

Gewald R, Grunwald C, Egerland U. Gewald R, et al. Among authors: egerland u. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4308-14. doi: 10.1016/j.bmcl.2013.05.099. Epub 2013 Jun 10. Bioorg Med Chem Lett. 2013. PMID: 23806553

5

Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia.

Grauer SM, Pulito VL, Navarra RL, Kelly MP, Kelley C, Graf R, Langen B, Logue S, Brennan J, Jiang L, Charych E, Egerland U, Liu F, Marquis KL, Malamas M, Hage T, Comery TA, Brandon NJ. Grauer SM, et al. Among authors: egerland u. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90. doi: 10.1124/jpet.109.155994. Epub 2009 Aug 6. J Pharmacol Exp Ther. 2009. PMID: 19661377

6

Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.

Gewald R, Rueger C, Grunwald C, Egerland U, Hoefgen N. Gewald R, et al. Among authors: egerland u. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6652-6. doi: 10.1016/j.bmcl.2011.09.065. Epub 2011 Sep 21. Bioorg Med Chem Lett. 2011. PMID: 21983442

7

Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines.

Wagner S, Scheunemann M, Dipper K, Egerland U, Hoefgen N, Steinbach J, Brust P. Wagner S, et al. Among authors: egerland u. Eur J Med Chem. 2016 Jan 1;107:97-108. doi: 10.1016/j.ejmech.2015.10.028. Epub 2015 Oct 19. Eur J Med Chem. 2016. PMID: 26562545

8

Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

Grunwald C, Rundfeldt C, Lankau HJ, Arnold T, Höfgen N, Dost R, Egerland U, Hofmann HJ, Unverferth K. Grunwald C, et al. Among authors: egerland u. J Med Chem. 2006 Mar 23;49(6):1855-66. doi: 10.1021/jm0509400. J Med Chem. 2006. PMID: 16539371

9

New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity.

Lankau HJ, Unverferth K, Grunwald C, Hartenhauer H, Heinecke K, Bernöster K, Dost R, Egerland U, Rundfeldt C. Lankau HJ, et al. Among authors: egerland u. Eur J Med Chem. 2007 Jun;42(6):873-9. doi: 10.1016/j.ejmech.2006.12.022. Epub 2007 Jan 12. Eur J Med Chem. 2007. PMID: 17303289

10

Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test.

Langen B, Dost R, Egerland U, Stange H, Hoefgen N. Langen B, et al. Among authors: egerland u. Psychopharmacology (Berl). 2012 May;221(2):249-59. doi: 10.1007/s00213-011-2567-y. Epub 2011 Nov 16. Psychopharmacology (Berl). 2012. PMID: 22147257

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