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A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling.
Li S, Jiang L, Beckmann K, Højen JF, Pessara U, Powers NE, de Graaf DM, Azam T, Lindenberger J, Eisenmesser EZ, Fischer S, Dinarello CA. Li S, et al. Among authors: eisenmesser ez. J Biol Chem. 2021 Jan-Jun;296:100630. doi: 10.1016/j.jbc.2021.100630. Epub 2021 Apr 3. J Biol Chem. 2021. PMID: 33823154 Free PMC article.
Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.
Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Cavalli G, et al. Among authors: eisenmesser ez. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13. Proc Natl Acad Sci U S A. 2017. PMID: 28193888 Free PMC article.
IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment.
Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, Dinarello CA, Albanesi C, Madonna S. Mercurio L, et al. Among authors: eisenmesser ez. Cell Death Dis. 2018 Oct 30;9(11):1104. doi: 10.1038/s41419-018-1143-3. Cell Death Dis. 2018. PMID: 30377293 Free PMC article.
Interleukin-37 monomer is the active form for reducing innate immunity.
Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Eisenmesser EZ, et al. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5514-5522. doi: 10.1073/pnas.1819672116. Epub 2019 Feb 28. Proc Natl Acad Sci U S A. 2019. PMID: 30819901 Free PMC article.
Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice.
Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. Ballak DB, et al. Among authors: eisenmesser ez. Aging Cell. 2020 Jan;19(1):e13074. doi: 10.1111/acel.13074. Epub 2019 Nov 21. Aging Cell. 2020. PMID: 31755162 Free PMC article.
Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
Klück V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, Crișan TO, Tausche AK, Riches P, Dalbeth N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M, Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea MG, Dinarello CA, Joosten LA. Klück V, et al. Among authors: eisenmesser ez. Ann Rheum Dis. 2020 Apr;79(4):536-544. doi: 10.1136/annrheumdis-2019-216233. Epub 2020 Feb 29. Ann Rheum Dis. 2020. PMID: 32114511
Extracellular and nuclear roles of IL-37 after spinal cord injury.
Amo-Aparicio J, Sanchez-Fernandez A, Li S, Eisenmesser EZ, Garlanda C, Dinarello CA, Lopez-Vales R. Amo-Aparicio J, et al. Among authors: eisenmesser ez. Brain Behav Immun. 2021 Jan;91:194-201. doi: 10.1016/j.bbi.2020.09.026. Epub 2020 Sep 28. Brain Behav Immun. 2021. PMID: 33002630 Free PMC article.
72 results