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Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies.
Moroy G, Denhez C, El Mourabit H, Toribio A, Dassonville A, Decarme M, Renault JH, Mirand C, Bellon G, Sapi J, Alix AJ, Hornebeck W, Bourguet E. Moroy G, et al. Among authors: el mourabit h. Bioorg Med Chem. 2007 Jul 15;15(14):4753-66. doi: 10.1016/j.bmc.2007.05.001. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17512742
Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity.
Ledour G, Moroy G, Rouffet M, Bourguet E, Guillaume D, Decarme M, Elmourabit H, Augé F, Alix AJ, Laronze JY, Bellon G, Hornebeck W, Sapi J. Ledour G, et al. Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. doi: 10.1016/j.bmc.2008.07.041. Epub 2008 Jul 20. Bioorg Med Chem. 2008. PMID: 18782669
Protective potential of the gallbladder in primary sclerosing cholangitis.
Cazzagon N, Gonzalez-Sanchez E, El-Mourabit H, Wendum D, Rainteau D, Humbert L, Corpechot C, Chazouillères O, Arrivé L, Housset C, Lemoinne S. Cazzagon N, et al. Among authors: el mourabit h. JHEP Rep. 2022 Dec 17;5(4):100649. doi: 10.1016/j.jhepr.2022.100649. eCollection 2023 Apr. JHEP Rep. 2022. PMID: 36923239 Free PMC article.
Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis.
Lei L, Bruneau A, El Mourabit H, Guégan J, Folseraas T, Lemoinne S, Karlsen TH, Hoareau B, Morichon R, Gonzalez-Sanchez E, Goumard C, Ratziu V, Charbord P, Gautheron J, Tacke F, Jaffredo T, Cadoret A, Housset C. Lei L, et al. Among authors: el mourabit h. Hepatology. 2022 Nov;76(5):1360-1375. doi: 10.1002/hep.32456. Epub 2022 Mar 29. Hepatology. 2022. PMID: 35278227 Free article.
Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice.
Gonzalez-Sanchez E, El Mourabit H, Jager M, Clavel M, Moog S, Vaquero J, Ledent T, Cadoret A, Gautheron J, Fouassier L, Wendum D, Chignard N, Housset C. Gonzalez-Sanchez E, et al. Among authors: el mourabit h. Biochim Biophys Acta Mol Basis Dis. 2021 Apr 1;1867(4):166067. doi: 10.1016/j.bbadis.2020.166067. Epub 2021 Jan 6. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33418034 Free article.
Diet-Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice.
Debray D, El Mourabit H, Merabtene F, Brot L, Ulveling D, Chrétien Y, Rainteau D, Moszer I, Wendum D, Sokol H, Housset C. Debray D, et al. Among authors: el mourabit h. Hepatol Commun. 2018 Oct 10;2(12):1533-1549. doi: 10.1002/hep4.1266. eCollection 2018 Dec. Hepatol Commun. 2018. PMID: 30556040 Free PMC article.
Culture Model of Rat Portal Myofibroblasts.
El Mourabit H, Loeuillard E, Lemoinne S, Cadoret A, Housset C. El Mourabit H, et al. Front Physiol. 2016 Mar 31;7:120. doi: 10.3389/fphys.2016.00120. eCollection 2016. Front Physiol. 2016. PMID: 27065888 Free PMC article.
21 results