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Chromosome errors in human eggs shape natural fertility over reproductive life span.
Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, Nikiforov D, Chan AC, Newnham LJ, Vogel I, Scarica C, Krapchev M, Taylor D, Kristensen SG, Cheng J, Ernst E, Bjørn AB, Colmorn LB, Blayney M, Elder K, Liss J, Hartshorne G, Grøndahl ML, Rienzi L, Ubaldi F, McCoy R, Lukaszuk K, Andersen CY, Schuh M, Hoffmann ER. Gruhn JR, et al. Among authors: elder k. Science. 2019 Sep 27;365(6460):1466-1469. doi: 10.1126/science.aav7321. Science. 2019. PMID: 31604276 Free PMC article.
Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs.
Zielinska AP, Bellou E, Sharma N, Frombach AS, Seres KB, Gruhn JR, Blayney M, Eckel H, Moltrecht R, Elder K, Hoffmann ER, Schuh M. Zielinska AP, et al. Among authors: elder k. Curr Biol. 2019 Nov 18;29(22):3749-3765.e7. doi: 10.1016/j.cub.2019.09.006. Epub 2019 Oct 31. Curr Biol. 2019. PMID: 31679939 Free PMC article.
Parental genome unification is highly error-prone in mammalian embryos.
Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M. Cavazza T, et al. Among authors: elder k. Cell. 2021 May 27;184(11):2860-2877.e22. doi: 10.1016/j.cell.2021.04.013. Epub 2021 May 7. Cell. 2021. PMID: 33964210 Free PMC article.
Mechanism of spindle pole organization and instability in human oocytes.
So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M. So C, et al. Among authors: elder k. Science. 2022 Feb 11;375(6581):eabj3944. doi: 10.1126/science.abj3944. Epub 2022 Feb 11. Science. 2022. PMID: 35143306
Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment.
Cheng S, Altmeppen G, So C, Welp LM, Penir S, Ruhwedel T, Menelaou K, Harasimov K, Stützer A, Blayney M, Elder K, Möbius W, Urlaub H, Schuh M. Cheng S, et al. Among authors: elder k. Science. 2022 Oct 21;378(6617):eabq4835. doi: 10.1126/science.abq4835. Epub 2022 Oct 21. Science. 2022. PMID: 36264786
284 results