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Inhibitors in AKTion: ATP-competitive vs allosteric.
Lazaro G, Kostaras E, Vivanco I. Lazaro G, et al. Among authors: kostaras e. Biochem Soc Trans. 2020 Jun 30;48(3):933-943. doi: 10.1042/BST20190777. Biochem Soc Trans. 2020. PMID: 32453400 Free PMC article. Review.
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, Shoemark A, Tsalikis A, de la Roche M, Michaelis M, Cinatl J Jr, Huang PH, Tanos BE. Jenks AD, et al. Among authors: kostaras e. Cell Rep. 2018 Jun 5;23(10):3042-3055. doi: 10.1016/j.celrep.2018.05.016. Cell Rep. 2018. PMID: 29874589 Free PMC article.
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.
Frentzas S, Simoneau E, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Nathan M, Wotherspoon A, Gao ZH, Shi Y, Van den Eynden G, Daley F, Peckitt C, Tan X, Salman A, Lazaris A, Gazinska P, Berg TJ, Eltahir Z, Ritsma L, Van Rheenen J, Khashper A, Brown G, Nystrom H, Sund M, Van Laere S, Loyer E, Dirix L, Cunningham D, Metrakos P, Reynolds AR. Frentzas S, et al. Among authors: kostaras e. Nat Med. 2016 Nov;22(11):1294-1302. doi: 10.1038/nm.4197. Epub 2016 Oct 17. Nat Med. 2016. PMID: 27748747 Free PMC article.
Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity.
Primikyri A, Chatziathanasiadou MV, Karali E, Kostaras E, Mantzaris MD, Hatzimichael E, Shin JS, Chi SW, Briasoulis E, Kolettas E, Gerothanassis IP, Tzakos AG. Primikyri A, et al. Among authors: kostaras e. ACS Chem Biol. 2014 Dec 19;9(12):2737-41. doi: 10.1021/cb500259e. Epub 2014 Oct 9. ACS Chem Biol. 2014. PMID: 25211642
The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.
Clarke CJ, Berg TJ, Birch J, Ennis D, Mitchell L, Cloix C, Campbell A, Sumpton D, Nixon C, Campbell K, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Jones JL, Haywood L, Pulleine E, Yin H, Strathdee D, Sansom O, Blyth K, McNeish I, Zanivan S, Reynolds AR, Norman JC. Clarke CJ, et al. Among authors: kostaras e. Curr Biol. 2016 Mar 21;26(6):755-65. doi: 10.1016/j.cub.2016.01.045. Epub 2016 Mar 3. Curr Biol. 2016. PMID: 26948875 Free PMC article.
Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models.
Bridgeman VL, Vermeulen PB, Foo S, Bilecz A, Daley F, Kostaras E, Nathan MR, Wan E, Frentzas S, Schweiger T, Hegedus B, Hoetzenecker K, Renyi-Vamos F, Kuczynski EA, Vasudev NS, Larkin J, Gore M, Dvorak HF, Paku S, Kerbel RS, Dome B, Reynolds AR. Bridgeman VL, et al. Among authors: kostaras e. J Pathol. 2017 Feb;241(3):362-374. doi: 10.1002/path.4845. Epub 2016 Dec 29. J Pathol. 2017. PMID: 27859259 Free PMC article.