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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
Acta Neuropathol. 2020 Dec;140(6):919-949. doi: 10.1007/s00401-020-02226-7. Epub 2020 Oct 3.
Acta Neuropathol. 2020.
PMID: 33009951
Free PMC article.
Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy.
Klein E, Hau AC, Oudin A, Golebiewska A, Niclou SP.
Klein E, et al.
Front Oncol. 2020 Dec 8;10:604121. doi: 10.3389/fonc.2020.604121. eCollection 2020.
Front Oncol. 2020.
PMID: 33364198
Free PMC article.
Review.
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Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors.
Oudin A, Baus V, Barthelemy V, Fabian C, Klein E, Dieterle M, Wantz M, Hau AC, Dording C, Bernard A, Michelucci A, Yabo YA, Kanli G, Keunen O, Bjerkvig R, Niclou SP, Golebiewska A.
Oudin A, et al. Among authors: klein e.
STAR Protoc. 2021 May 12;2(2):100534. doi: 10.1016/j.xpro.2021.100534. eCollection 2021 Jun 18.
STAR Protoc. 2021.
PMID: 34027491
Free PMC article.
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AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.
Schuster A, Klein E, Neirinckx V, Knudsen AM, Fabian C, Hau AC, Dieterle M, Oudin A, Nazarov PV, Golebiewska A, Muller A, Perez-Hernandez D, Rodius S, Dittmar G, Bjerkvig R, Herold-Mende C, Klink B, Kristensen BW, Niclou SP.
Schuster A, et al. Among authors: klein e.
Nat Commun. 2020 Dec 11;11(1):6366. doi: 10.1038/s41467-020-20029-y.
Nat Commun. 2020.
PMID: 33311477
Free PMC article.
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The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.
Neirinckx V, Hau AC, Schuster A, Fritah S, Tiemann K, Klein E, Nazarov PV, Matagne A, Szpakowska M, Meyrath M, Chevigné A, Schmidt MHH, Niclou SP.
Neirinckx V, et al. Among authors: klein e.
Neurooncol Adv. 2019 Sep 6;1(1):vdz024. doi: 10.1093/noajnl/vdz024. eCollection 2019 May-Dec.
Neurooncol Adv. 2019.
PMID: 32642659
Free PMC article.
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