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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL. Barekatain Y, et al. Among authors: behr ei. Nat Commun. 2021 Jul 9;12(1):4228. doi: 10.1038/s41467-021-24240-3. Nat Commun. 2021. PMID: 34244484 Free PMC article.
Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism.
Khadka S, Lin YH, Ackroyd J, Chen YA, Sheng Y, Qian W, Guo S, Chen Y, Behr E, Barekatain Y, Uddin N, Arthur K, Yan V, Hsu WH, Chang Q, Poral A, Tran T, Chaurasia S, Georgiou DK, Asara JM, Barthel FP, Millward SW, DePinho RA, Muller FL. Khadka S, et al. Among authors: behr e. bioRxiv [Preprint]. 2023 Oct 19:2023.05.07.539744. doi: 10.1101/2023.05.07.539744. bioRxiv. 2023. PMID: 37214825 Free PMC article. Preprint.
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma.
Khadka S, Arthur K, Barekatain Y, Behr E, Washington M, Ackroyd J, Crowley K, Suriyamongkol P, Lin YH, Pham CD, Zielinski R, Trujillo M, Galligan J, Georgiou DK, Asara J, Muller F. Khadka S, et al. Among authors: behr e. Cancer Metab. 2021 Jun 25;9(1):27. doi: 10.1186/s40170-021-00259-4. Cancer Metab. 2021. PMID: 34172075 Free PMC article.