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Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.
Kfoury Y, Baryawno N, Severe N, Mei S, Gustafsson K, Hirz T, Brouse T, Scadden EW, Igolkina AA, Kokkaliaris K, Choi BD, Barkas N, Randolph MA, Shin JH, Saylor PJ, Scadden DT, Sykes DB, Kharchenko PV; as part of the Boston Bone Metastases Consortium. Kfoury Y, et al. Among authors: scadden ew. Cancer Cell. 2021 Nov 8;39(11):1464-1478.e8. doi: 10.1016/j.ccell.2021.09.005. Epub 2021 Oct 15. Cancer Cell. 2021. PMID: 34719426 Free PMC article.
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf RZ, Saez B, Sharda A, van Gastel N, Yu VWC, Baryawno N, Scadden EW, Acharya S, Chattophadhyay S, Huang C, Viswanathan V, S'aulis D, Cobert J, Sykes DB, Keibler MA, Das S, Hutchinson JN, Churchill M, Mukherjee S, Lee D, Mercier F, Doench J, Bullinger L, Logan DJ, Schreiber S, Stephanopoulos G, Rizzo WB, Scadden DT. Yusuf RZ, et al. Among authors: scadden ew. Blood. 2020 Sep 10;136(11):1303-1316. doi: 10.1182/blood.2019001808. Blood. 2020. PMID: 32458004 Free PMC article.
Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance.
Çoku J, Booth DM, Skoda J, Pedrotty MC, Vogel J, Liu K, Vu A, Carpenter EL, Ye JC, Chen MA, Dunbar P, Scadden E, Yun TD, Nakamaru-Ogiso E, Area-Gomez E, Li Y, Goldsmith KC, Reynolds CP, Hajnoczky G, Hogarty MD. Çoku J, et al. Among authors: scadden e. EMBO J. 2022 Apr 19;41(8):e108272. doi: 10.15252/embj.2021108272. Epub 2022 Feb 25. EMBO J. 2022. PMID: 35211994 Free PMC article.
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.
Severe N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M, Scadden DT. Severe N, et al. Among authors: scadden ew. Cell Stem Cell. 2019 Oct 3;25(4):570-583.e7. doi: 10.1016/j.stem.2019.06.003. Epub 2019 Jul 3. Cell Stem Cell. 2019. PMID: 31279774 Free PMC article.