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Page 1
Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation.
Reinhardt L, Musacchio F, Bichmann M, Behrendt A, Ercan-Herbst E, Stein J, Becher I, Haberkant P, Mader J, Schöndorf DC, Schmitt M, Korffmann J, Reinhardt P, Pohl C, Savitski M, Klein C, Gasparini L, Fuhrmann M, Ehrnhoefer DE. Reinhardt L, et al. Among authors: ercan herbst e. Neurobiol Dis. 2023 Jun 15;182:106126. doi: 10.1016/j.nbd.2023.106126. Epub 2023 Apr 20. Neurobiol Dis. 2023. PMID: 37086756 Free article.
Tau in the brain interstitial fluid is fragmented and seeding-competent.
Barini E, Plotzky G, Mordashova Y, Hoppe J, Rodriguez-Correa E, Julier S, LePrieult F, Mairhofer I, Mezler M, Biesinger S, Cik M, Meinhardt MW, Ercan-Herbst E, Ehrnhoefer DE, Striebinger A, Bodie K, Klein C, Gasparini L, Schlegel K. Barini E, et al. Among authors: ercan herbst e. Neurobiol Aging. 2022 Jan;109:64-77. doi: 10.1016/j.neurobiolaging.2021.09.013. Epub 2021 Sep 17. Neurobiol Aging. 2022. PMID: 34655982 Free article.
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE. Bichmann M, et al. Among authors: ercan herbst e. Mol Neurodegener. 2021 Jul 2;16(1):46. doi: 10.1186/s13024-021-00468-x. Mol Neurodegener. 2021. PMID: 34215303 Free PMC article.
Asparagine endopeptidase cleaves tau at N167 after uptake into microglia.
Behrendt A, Bichmann M, Ercan-Herbst E, Haberkant P, Schöndorf DC, Wolf M, Fahim SA, Murolo E, Ehrnhoefer DE. Behrendt A, et al. Among authors: ercan herbst e. Neurobiol Dis. 2019 Oct;130:104518. doi: 10.1016/j.nbd.2019.104518. Epub 2019 Jun 21. Neurobiol Dis. 2019. PMID: 31229689
A transistor-based label-free immunosensor for rapid detection of tau protein.
García-Chamé MÁ, Gutiérrez-Sanz Ó, Ercan-Herbst E, Haustein N, Filipiak MS, Ehrnhöfer DE, Tarasov A. García-Chamé MÁ, et al. Among authors: ercan herbst e. Biosens Bioelectron. 2020 Jul 1;159:112129. doi: 10.1016/j.bios.2020.112129. Epub 2020 Mar 4. Biosens Bioelectron. 2020. PMID: 32364931