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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Raffel S, et al. Among authors: erez a. Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8. Nature. 2017. PMID: 29144447
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Ulitsky I, Nagamani SC, Ruppin E, Erez A. Rabinovich S, et al. Among authors: erez a. Nature. 2015 Nov 19;527(7578):379-383. doi: 10.1038/nature15529. Epub 2015 Nov 11. Nature. 2015. PMID: 26560030 Free PMC article.
Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Raffel S, et al. Among authors: erez a. Nature. 2018 Aug;560(7718):E28. doi: 10.1038/s41586-018-0403-9. Nature. 2018. PMID: 30069041
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors.
Keshet R, Lee JS, Adler L, Iraqi M, Ariav Y, Lim LQJ, Lerner S, Rabinovich S, Oren R, Katzir R, Weiss Tishler H, Stettner N, Goldman O, Landesman H, Galai S, Kuperman Y, Kuznetsov Y, Brandis A, Mehlman T, Malitsky S, Itkin M, Koehler SE, Zhao Y, Talsania K, Shen TW, Peled N, Ulitsky I, Porgador A, Ruppin E, Erez A. Keshet R, et al. Among authors: erez a. Nat Cancer. 2020 Sep;1(9):894-908. doi: 10.1038/s43018-020-0106-7. Epub 2020 Aug 31. Nat Cancer. 2020. PMID: 35121952
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Sciacovelli M, Dugourd A, Jimenez LV, Yang M, Nikitopoulou E, Costa ASH, Tronci L, Caraffini V, Rodrigues P, Schmidt C, Ryan DG, Young T, Zecchini VR, Rossi SH, Massie C, Lohoff C, Masid M, Hatzimanikatis V, Kuppe C, Von Kriegsheim A, Kramann R, Gnanapragasam V, Warren AY, Stewart GD, Erez A, Vanharanta S, Saez-Rodriguez J, Frezza C. Sciacovelli M, et al. Among authors: erez a. Nat Commun. 2022 Dec 20;13(1):7830. doi: 10.1038/s41467-022-35036-4. Nat Commun. 2022. PMID: 36539415 Free PMC article.
Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes.
Nobs SP, Kolodziejczyk AA, Adler L, Horesh N, Botscharnikow C, Herzog E, Mohapatra G, Hejndorf S, Hodgetts RJ, Spivak I, Schorr L, Fluhr L, Kviatcovsky D, Zacharia A, Njuki S, Barasch D, Stettner N, Dori-Bachash M, Harmelin A, Brandis A, Mehlman T, Erez A, He Y, Ferrini S, Puschhof J, Shapiro H, Kopf M, Moussaieff A, Abdeen SK, Elinav E. Nobs SP, et al. Among authors: erez a. Nature. 2023 Dec;624(7992):645-652. doi: 10.1038/s41586-023-06803-0. Epub 2023 Dec 13. Nature. 2023. PMID: 38093014 Free PMC article.
Requirement of argininosuccinate lyase for systemic nitric oxide production.
Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. Erez A, et al. Nat Med. 2011 Nov 13;17(12):1619-26. doi: 10.1038/nm.2544. Nat Med. 2011. PMID: 22081021 Free PMC article.
160 results