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Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.
Vaziri-Gohar A, Cassel J, Mohammed FS, Zarei M, Hue JJ, Hajihassani O, Graor HJ, Srikanth YVV, Karim SA, Abbas A, Prendergast E, Chen V, Katayama ES, Dukleska K, Khokhar I, Andren A, Zhang L, Wu C, Erokwu B, Flask CA, Zarei M, Wang R, Rothermel LD, Romani AMP, Bowers J, Getts R, Tatsuoka C, Morton JP, Bederman I, Brunengraber H, Lyssiotis CA, Salvino JM, Brody JR, Winter JM. Vaziri-Gohar A, et al. Among authors: prendergast e. Nat Cancer. 2022 Jul;3(7):852-865. doi: 10.1038/s43018-022-00393-y. Epub 2022 Jun 9. Nat Cancer. 2022. PMID: 35681100 Free PMC article.
Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis.
Ramachandran K, Futtner CR, Sommars MA, Quattrocelli M, Omura Y, Fruzyna E, Wang JC, Waldeck NJ, Senagolage MD, Telles CG, Demonbreun AR, Prendergast E, Lai N, Arango D, Bederman IR, McNally EM, Barish GD. Ramachandran K, et al. Among authors: prendergast e. Nat Metab. 2024 Feb;6(2):304-322. doi: 10.1038/s42255-024-00983-3. Epub 2024 Feb 9. Nat Metab. 2024. PMID: 38337096 Free PMC article.
Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial.
Costa ACS, Brandão AC, Boada R, Barrionuevo VL, Taylor HG, Roth E, Stasko MR, Johnson MW, Assir FF, Roberto MP, Salmona P, Abreu-Silveira G, Bederman I, Prendergast E, Hüls A, Abrishamcar S, Mustacchi Z, Scheidemantel T, Roizen NJ, Ruedrich S. Costa ACS, et al. Among authors: prendergast e. Lancet Neurol. 2022 Jan;21(1):31-41. doi: 10.1016/S1474-4422(21)00369-0. Lancet Neurol. 2022. PMID: 34942135 Clinical Trial.
A Synthetic Small RNA Homologous to the D-Loop Transcript of mtDNA Enhances Mitochondrial Bioenergetics.
Mathuram TL, Townsend DM, Lynch VJ, Bederman I, Ye ZW, Zhang J, Sigurdson WJ, Prendergast E, Jobava R, Ferruzza JP, D'Angelo MR, Hatzoglou M, Perry Y, Blumental-Perry A. Mathuram TL, et al. Among authors: prendergast e. Front Physiol. 2022 Apr 6;13:772313. doi: 10.3389/fphys.2022.772313. eCollection 2022. Front Physiol. 2022. PMID: 35464086 Free PMC article.
Studies of ApoD-/- and ApoD-/-ApoE-/- mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels.
El-Darzi N, Mast N, Petrov AM, Dao T, Astafev AA, Saadane A, Prendergast E, Schwarz E, Bederman I, Pikuleva IA. El-Darzi N, et al. Among authors: prendergast e. Cell Mol Life Sci. 2021 Feb;78(3):963-983. doi: 10.1007/s00018-020-03546-3. Epub 2020 May 21. Cell Mol Life Sci. 2021. PMID: 32440710 Free PMC article.