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Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases.
Boivin M, Deng J, Pfister V, Grandgirard E, Oulad-Abdelghani M, Morlet B, Ruffenach F, Negroni L, Koebel P, Jacob H, Riet F, Dijkstra AA, McFadden K, Clayton WA, Hong D, Miyahara H, Iwasaki Y, Sone J, Wang Z, Charlet-Berguerand N. Boivin M, et al. Among authors: grandgirard e. Neuron. 2021 Jun 2;109(11):1825-1835.e5. doi: 10.1016/j.neuron.2021.03.038. Epub 2021 Apr 21. Neuron. 2021. PMID: 33887199 Free PMC article.
CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake.
Vivot K, Meszaros G, Pangou E, Zhang Z, Qu M, Erbs E, Yeghiazaryan G, Quiñones M, Grandgirard E, Schneider A, Clauss-Creusot E, Charlet A, Faour M, Martin C, Berditchevski F, Sumara I, Luquet S, Kloppenburg P, Nogueiras R, Ricci R. Vivot K, et al. Among authors: grandgirard e. Nat Metab. 2023 Jun;5(6):1045-1058. doi: 10.1038/s42255-023-00814-x. Epub 2023 Jun 5. Nat Metab. 2023. PMID: 37277610
Competition between transcription and loop extrusion modulates promoter and enhancer dynamics.
Platania A, Erb C, Barbieri M, Molcrette B, Grandgirard E, de Kort MA, Meaburn K, Taylor T, Shchuka VM, Kocanova S, Oliveira GM, Mitchell JA, Soutoglou E, Lenstra TL, Molina N, Papantonis A, Bystricky K, Sexton T. Platania A, et al. Among authors: grandgirard e. bioRxiv [Preprint]. 2023 Apr 26:2023.04.25.538222. doi: 10.1101/2023.04.25.538222. bioRxiv. 2023. PMID: 37162887 Free PMC article. Preprint.
Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis.
Souali-Crespo S, Condrea D, Vernet N, Féret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB. Souali-Crespo S, et al. Among authors: grandgirard e. Development. 2023 Dec 15;150(24):dev201710. doi: 10.1242/dev.201710. Epub 2023 Dec 11. Development. 2023. PMID: 38078651 Free PMC article.
MOSPD2 is an endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis.
Zouiouich M, Di Mattia T, Martinet A, Eichler J, Wendling C, Tomishige N, Grandgirard E, Fuggetta N, Fromental-Ramain C, Mizzon G, Dumesnil C, Carpentier M, Reina-San-Martin B, Mathelin C, Schwab Y, Thiam AR, Kobayashi T, Drin G, Tomasetto C, Alpy F. Zouiouich M, et al. Among authors: grandgirard e. J Cell Biol. 2022 Jun 6;221(6):e202110044. doi: 10.1083/jcb.202110044. Epub 2022 Apr 7. J Cell Biol. 2022. PMID: 35389430 Free PMC article.
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression.
Pangou E, Bielska O, Guerber L, Schmucker S, Agote-Arán A, Ye T, Liao Y, Puig-Gamez M, Grandgirard E, Kleiss C, Liu Y, Compe E, Zhang Z, Aebersold R, Ricci R, Sumara I. Pangou E, et al. Among authors: grandgirard e. Cell Rep. 2021 May 18;35(7):109129. doi: 10.1016/j.celrep.2021.109129. Cell Rep. 2021. PMID: 34010649 Free article.
Competition between transcription and loop extrusion modulates promoter and enhancer dynamics.
Sexton T, Platania A, Erb C, Barbieri M, Molcrette B, Grandgirard E, de Kort M, Meabum K, Taylor T, Shchuka V, Kocanova S, Oliveira G, Mitchell J, Soutoglou E, Lenstra T, Molina N, Papantonis A, Bystricky K. Sexton T, et al. Among authors: grandgirard e. Res Sq [Preprint]. 2023 Aug 16:rs.3.rs-3164817. doi: 10.21203/rs.3.rs-3164817/v1. Res Sq. 2023. PMID: 37645793 Free PMC article. Preprint.
Vascularization of Patient-Derived Tumoroid from Non-Small-Cell Lung Cancer and Its Microenvironment.
Seitlinger J, Nounsi A, Idoux-Gillet Y, Santos Pujol E, Lê H, Grandgirard E, Olland A, Lindner V, Zaupa C, Balloul JM, Quemeneur E, Massard G, Falcoz PE, Hua G, Benkirane-Jessel N. Seitlinger J, et al. Among authors: grandgirard e. Biomedicines. 2022 May 10;10(5):1103. doi: 10.3390/biomedicines10051103. Biomedicines. 2022. PMID: 35625840 Free PMC article.
SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2.
Niewiadomska-Cimicka A, Doussau F, Perot JB, Roux MJ, Keime C, Hache A, Piguet F, Novati A, Weber C, Yalcin B, Meziane H, Champy MF, Grandgirard E, Karam A, Messaddeq N, Eisenmann A, Brouillet E, Nguyen HHP, Flament J, Isope P, Trottier Y. Niewiadomska-Cimicka A, et al. Among authors: grandgirard e. J Neurosci. 2021 Jun 2;41(22):4910-4936. doi: 10.1523/JNEUROSCI.1882-20.2021. Epub 2021 Apr 22. J Neurosci. 2021. PMID: 33888607 Free PMC article.