Espinosa A - Search Results

1

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies.

Strandberg L, Ambrosi A, Espinosa A, Ottosson L, Eloranta ML, Zhou W, Elfving A, Greenfield E, Kuchroo VK, Wahren-Herlenius M. Strandberg L, et al. Among authors: espinosa a. J Clin Immunol. 2008 May;28(3):220-31. doi: 10.1007/s10875-007-9157-0. J Clin Immunol. 2008. PMID: 18071879

2

Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome.

Ottosson L, Hennig J, Espinosa A, Brauner S, Wahren-Herlenius M, Sunnerhagen M. Ottosson L, et al. Among authors: espinosa a. Mol Immunol. 2006 Feb;43(6):588-98. doi: 10.1016/j.molimm.2005.04.013. Mol Immunol. 2006. PMID: 15916807

3

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

Popovic K, Ek M, Espinosa A, Padyukov L, Harris HE, Wahren-Herlenius M, Nyberg F. Popovic K, et al. Among authors: espinosa a. Arthritis Rheum. 2005 Nov;52(11):3639-45. doi: 10.1002/art.21398. Arthritis Rheum. 2005. PMID: 16255056 Free article.

4

The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.

Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius M. Espinosa A, et al. J Immunol. 2006 May 15;176(10):6277-85. doi: 10.4049/jimmunol.176.10.6277. J Immunol. 2006. PMID: 16670339

5

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.

Espinosa A, Oke V, Elfving A, Nyberg F, Covacu R, Wahren-Herlenius M. Espinosa A, et al. Exp Cell Res. 2008 Dec 10;314(20):3605-13. doi: 10.1016/j.yexcr.2008.09.011. Epub 2008 Sep 25. Exp Cell Res. 2008. PMID: 18845142

6

High Ro52 expression in spontaneous and UV-induced cutaneous inflammation.

Oke V, Vassilaki I, Espinosa A, Strandberg L, Kuchroo VK, Nyberg F, Wahren-Herlenius M. Oke V, et al. Among authors: espinosa a. J Invest Dermatol. 2009 Aug;129(8):2000-10. doi: 10.1038/jid.2008.453. Epub 2009 Feb 5. J Invest Dermatol. 2009. PMID: 19194477 Free article.

7

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.

Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M. Espinosa A, et al. J Exp Med. 2009 Aug 3;206(8):1661-71. doi: 10.1084/jem.20090585. Epub 2009 Jul 27. J Exp Med. 2009. PMID: 19635858 Free PMC article.

8

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

Higgs R, Lazzari E, Wynne C, Ní Gabhann J, Espinosa A, Wahren-Herlenius M, Jefferies CA. Higgs R, et al. Among authors: espinosa a. PLoS One. 2010 Jul 26;5(7):e11776. doi: 10.1371/journal.pone.0011776. PLoS One. 2010. PMID: 20668674 Free PMC article.

9

The complexity of Sjögren's syndrome: novel aspects on pathogenesis.

Jonsson R, Vogelsang P, Volchenkov R, Espinosa A, Wahren-Herlenius M, Appel S. Jonsson R, et al. Among authors: espinosa a. Immunol Lett. 2011 Dec 30;141(1):1-9. doi: 10.1016/j.imlet.2011.06.007. Epub 2011 Jul 12. Immunol Lett. 2011. PMID: 21777618 Review.

10

Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.

Espinosa A, Hennig J, Ambrosi A, Anandapadmanaban M, Abelius MS, Sheng Y, Nyberg F, Arrowsmith CH, Sunnerhagen M, Wahren-Herlenius M. Espinosa A, et al. J Biol Chem. 2011 Oct 21;286(42):36478-91. doi: 10.1074/jbc.M111.241786. Epub 2011 Aug 23. J Biol Chem. 2011. PMID: 21862588 Free PMC article.

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