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GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells.
Fernandez RJ, Gardner ZJG, Slovik KJ, Liberti DC, Estep KN, Yang W, Chen Q, Santini GT, Perez JV, Root S, Bhatia R, Tobias JW, Babu A, Morley MP, Frank DB, Morrisey EE, Lengner CJ, Johnson FB. Fernandez RJ, et al. Among authors: estep kn. Elife. 2022 May 13;11:e64430. doi: 10.7554/eLife.64430. Elife. 2022. PMID: 35559731 Free PMC article.
Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.
Butler TJ, Estep KN, Sommers JA, Maul RW, Moore AZ, Bandinelli S, Cucca F, Tuke MA, Wood AR, Bharti SK, Bogenhagen DF, Yakubovskaya E, Garcia-Diaz M, Guilliam TA, Byrd AK, Raney KD, Doherty AJ, Ferrucci L, Schlessinger D, Ding J, Brosh RM. Butler TJ, et al. Among authors: estep kn. Hum Mol Genet. 2020 May 28;29(8):1292-1309. doi: 10.1093/hmg/ddaa043. Hum Mol Genet. 2020. PMID: 32191790 Free PMC article.