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Page 1
From structure to sequence: Antibody discovery using cryoEM.
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB. Antanasijevic A, et al. Sci Adv. 2022 Jan 21;8(3):eabk2039. doi: 10.1126/sciadv.abk2039. Epub 2022 Jan 19. Sci Adv. 2022. PMID: 35044813 Free PMC article.
Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies.
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD. Cottrell CA, et al. Cell Rep. 2021 Nov 2;37(5):109922. doi: 10.1016/j.celrep.2021.109922. Cell Rep. 2021. PMID: 34731616 Free PMC article.
The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization.
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW. Schorcht A, et al. J Virol. 2022 Jan 12;96(1):e0155221. doi: 10.1128/JVI.01552-21. Epub 2021 Oct 20. J Virol. 2022. PMID: 34669426 Free PMC article.
Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.
van Schooten J, van Haaren MM, Li H, McCoy LE, Havenar-Daughton C, Cottrell CA, Burger JA, van der Woude P, Helgers LC, Tomris I, Labranche CC, Montefiori DC, Ward AB, Burton DR, Moore JP, Sanders RW, Crotty S, Shaw GM, van Gils MJ. van Schooten J, et al. PLoS Pathog. 2021 Aug 25;17(8):e1009736. doi: 10.1371/journal.ppat.1009736. eCollection 2021 Aug. PLoS Pathog. 2021. PMID: 34432859 Free PMC article.
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Peña AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB. Antanasijevic A, et al. Nat Commun. 2021 Aug 10;12(1):4817. doi: 10.1038/s41467-021-25087-4. Nat Commun. 2021. PMID: 34376662 Free PMC article.
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, Torrents de la Peña A, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. van Haaren MM, et al. J Virol. 2021 Aug 10;95(17):e0009421. doi: 10.1128/JVI.00094-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34076487 Free PMC article.
Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike.
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW. Derking R, et al. Cell Rep. 2021 Apr 6;35(1):108933. doi: 10.1016/j.celrep.2021.108933. Cell Rep. 2021. PMID: 33826885 Free PMC article.
The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.
Charles TP, Burton SL, Arunachalam PS, Cottrell CA, Sewall LM, Bollimpelli VS, Gangadhara S, Dey AK, Ward AB, Shaw GM, Hunter E, Amara RR, Pulendran B, van Gils MJ, Derdeyn CA. Charles TP, et al. PLoS Pathog. 2021 Feb 8;17(2):e1009257. doi: 10.1371/journal.ppat.1009257. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33556148 Free PMC article.
30 results