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GCN2 adapts protein synthesis to scavenging-dependent growth.
Cell Syst. 2022 Feb 16;13(2):158-172.e9. doi: 10.1016/j.cels.2021.09.014. Epub 2021 Oct 26.
Cell Syst. 2022.
PMID: 34706266
Free PMC article.
mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.
Nofal M, Zhang K, Han S, Rabinowitz JD.
Nofal M, et al.
Mol Cell. 2017 Sep 21;67(6):936-946.e5. doi: 10.1016/j.molcel.2017.08.011. Epub 2017 Sep 14.
Mol Cell. 2017.
PMID: 28918901
Free PMC article.
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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.
Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD.
Kamphorst JJ, et al.
Cancer Res. 2015 Feb 1;75(3):544-53. doi: 10.1158/0008-5472.CAN-14-2211.
Cancer Res. 2015.
PMID: 25644265
Free PMC article.
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