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Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice.
BMC Microbiol. 2019 Mar 12;19(1):57. doi: 10.1186/s12866-019-1425-7.
BMC Microbiol. 2019.
PMID: 30871463
Free PMC article.
Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance.
Skarra DV, Hernández-Carretero A, Rivera AJ, Anvar AR, Thackray VG.
Skarra DV, et al.
Endocrinology. 2017 Sep 1;158(9):2988-3003. doi: 10.1210/en.2016-1898.
Endocrinology. 2017.
PMID: 28911175
Free PMC article.
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The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome.
Kelley ST, Skarra DV, Rivera AJ, Thackray VG.
Kelley ST, et al.
PLoS One. 2016 Jan 5;11(1):e0146509. doi: 10.1371/journal.pone.0146509. eCollection 2016.
PLoS One. 2016.
PMID: 26731268
Free PMC article.
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FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes.
Skarra DV, Thackray VG.
Skarra DV, et al.
Mol Cell Endocrinol. 2015 Apr 15;405:14-24. doi: 10.1016/j.mce.2015.02.006. Epub 2015 Feb 9.
Mol Cell Endocrinol. 2015.
PMID: 25676570
Free PMC article.
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Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes.
Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray VG.
Park CH, et al.
PLoS One. 2014 Nov 25;9(11):e113839. doi: 10.1371/journal.pone.0113839. eCollection 2014.
PLoS One. 2014.
PMID: 25423188
Free PMC article.
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Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.
Skarra DV, Arriola DJ, Benson CA, Thackray VG.
Skarra DV, et al.
Mol Endocrinol. 2013 Nov;27(11):1825-39. doi: 10.1210/me.2013-1185. Epub 2013 Sep 24.
Mol Endocrinol. 2013.
PMID: 24065703
Free PMC article.
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FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.
Arriola DJ, Mayo SL, Skarra DV, Benson CA, Thackray VG.
Arriola DJ, et al.
J Biol Chem. 2012 Sep 28;287(40):33424-35. doi: 10.1074/jbc.M112.362103. Epub 2012 Aug 3.
J Biol Chem. 2012.
PMID: 22865884
Free PMC article.
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