Faltynek CR - Search Results

1

Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats.

McGaraughty S, Segreti JA, Fryer RM, Brown BS, Faltynek CR, Kym PR. McGaraughty S, et al. Among authors: faltynek cr. Brain Res. 2009 May 1;1268:58-67. doi: 10.1016/j.brainres.2009.02.018. Epub 2009 Feb 21. Brain Res. 2009. PMID: 19236852

2

Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat.

Wismer CT, Faltynek CR, Jarvis MF, McGaraughty S. Wismer CT, et al. Among authors: faltynek cr. Brain Res. 2003 Mar 7;965(1-2):187-93. doi: 10.1016/s0006-8993(02)04193-8. Brain Res. 2003. PMID: 12591137

3

Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.

McGaraughty S, Chu KL, Faltynek CR, Jarvis MF. McGaraughty S, et al. Among authors: faltynek cr. J Neurophysiol. 2006 Jan;95(1):18-25. doi: 10.1152/jn.00560.2005. Epub 2005 Sep 14. J Neurophysiol. 2006. PMID: 16162831 Free article.

4

Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.

McGaraughty S, Chu KL, Brown BS, Zhu CZ, Zhong C, Joshi SK, Honore P, Faltynek CR, Jarvis MF. McGaraughty S, et al. Among authors: faltynek cr. J Neurophysiol. 2008 Dec;100(6):3158-66. doi: 10.1152/jn.90768.2008. Epub 2008 Oct 1. J Neurophysiol. 2008. PMID: 18829846 Free article.

5

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.

Honore P, Chandran P, Hernandez G, Gauvin DM, Mikusa JP, Zhong C, Joshi SK, Ghilardi JR, Sevcik MA, Fryer RM, Segreti JA, Banfor PN, Marsh K, Neelands T, Bayburt E, Daanen JF, Gomtsyan A, Lee CH, Kort ME, Reilly RM, Surowy CS, Kym PR, Mantyh PW, Sullivan JP, Jarvis MF, Faltynek CR. Honore P, et al. Among authors: faltynek cr. Pain. 2009 Mar;142(1-2):27-35. doi: 10.1016/j.pain.2008.11.004. Epub 2009 Jan 9. Pain. 2009. PMID: 19135797

6

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR. Chen J, et al. Among authors: faltynek cr. Pain. 2011 May;152(5):1165-1172. doi: 10.1016/j.pain.2011.01.049. Epub 2011 Mar 12. Pain. 2011. PMID: 21402443

7

Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.

McGaraughty S, Chu KL, Bitner RS, Martino B, El Kouhen R, Han P, Nikkel AL, Burgard EC, Faltynek CR, Jarvis MF. McGaraughty S, et al. Among authors: faltynek cr. J Neurophysiol. 2003 Oct;90(4):2702-10. doi: 10.1152/jn.00433.2003. Epub 2003 Jun 18. J Neurophysiol. 2003. PMID: 12815018 Free article.

8

Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity.

Chu KL, Faltynek CR, Jarvis MF, McGaraughty S. Chu KL, et al. Among authors: faltynek cr. Neurosci Lett. 2004 Nov 30;372(1-2):123-6. doi: 10.1016/j.neulet.2004.09.025. Neurosci Lett. 2004. PMID: 15531101

9

Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.

Drizin I, Gomtsyan A, Bayburt EK, Schmidt RG, Zheng GZ, Perner RJ, DiDomenico S, Koenig JR, Turner SC, Jinkerson TK, Brown BS, Keddy RG, McDonald HA, Honore P, Wismer CT, Marsh KC, Wetter JM, Polakowski JS, Segreti JA, Jarvis MF, Faltynek CR, Lee CH. Drizin I, et al. Among authors: faltynek cr. Bioorg Med Chem. 2006 Jul 15;14(14):4740-9. doi: 10.1016/j.bmc.2006.03.027. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621571

10

A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

McGaraughty S, Chu KL, Scanio MJ, Kort ME, Faltynek CR, Jarvis MF. McGaraughty S, et al. Among authors: faltynek cr. J Pharmacol Exp Ther. 2008 Mar;324(3):1204-11. doi: 10.1124/jpet.107.134148. Epub 2007 Dec 18. J Pharmacol Exp Ther. 2008. PMID: 18089840

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